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Observing the water handling in humans to resolve the role of the interstitium: preliminary results of the usability of deuterium oxide and bio-impedance analysis - a pilot analysis

Pauwaert, Kim ; Bodé, Samuel ; Alwis, Upeshka Sewwandi ; Mylle, Toon ; Boeckx, Pascal ; Delanghe, Joris ; Everaert, Karel ; Roggeman, Saskia

Isotopes in environmental and health studies, 2022-03, Vol.58 (1), p.99-110 [Periódico revisado por pares]

England: Taylor & Francis

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Observing the water handling in humans to resolve the role of the interstitium: preliminary results of the usability of deuterium oxide and bio-impedance analysis - a pilot analysis
Autor: Pauwaert, Kim ; Bodé, Samuel ; Alwis, Upeshka Sewwandi ; Mylle, Toon ; Boeckx, Pascal ; Delanghe, Joris ; Everaert, Karel ; Roggeman, Saskia
Assuntos: Blood ; Body Composition ; Body Water ; Deuterium ; Deuterium Oxide ; Electric Impedance ; Electrical impedance ; extracellular fluid ; Female ; Gastrointestinal system ; Gastrointestinal tract ; Gender ; Gender aspects ; Heavy water ; Humans ; hydrogen-2 ; Impedance ; Ingestion ; Male ; Men ; nocturia ; Posture ; Prospective Studies ; Sex differences ; tracer technique ; Water ; Women
É parte de: Isotopes in environmental and health studies, 2022-03, Vol.58 (1), p.99-110
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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Descrição: The aim of this research was to evaluate the relevance of using deuterium oxide ( 2 H 2 O) and bio-impedance analysis (BIA) to assess size and function of the interstitium for urological research. Nineteen volunteers were recruited to this prospective trial combining ingestion of 2 H 2 O and BIA. Blood samples were obtained every 10 min after ingestion of 2 H 2 O. Urine was collected before and after the experiment. BIA was performed every 5 min. Body position was alternated to study the effect on fluid distribution. First order kinetics were assumed for the uptake of 2 H 2 O from the gastrointestinal tract to the blood. Sex seemed to have an influence with a significantly slower exchange for women (p = 0.041, men: 0.052 min -1 , women: 0.038 min -1 ). Impedance measured in legs (men: p = 0.012, women: p = 0.008) and trunk (both p < 0.001) decreased significantly with posture change. These changes probably reflect the orthostatic redistribution of fluid with an increase of fluid in both trunk and legs. Both methods were tested and found to be useful for further urological research. Significant gender differences in 2 H 2 O uptake dynamics from the gastrointestinal pool were observed. An impact of posture changes on the electrical impedance measured was observed.
Editor: England: Taylor & Francis
Idioma: Inglês;Alemão;Russo

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Observing the water handling in humans to resolve the role of the interstitium: preliminary results of the usability of deuterium oxide and bio-impedance analysis - a pilot analysis

Pauwaert, Kim ; Bodé, Samuel ; Alwis, Upeshka Sewwandi ; Mylle, Toon ; Boeckx, Pascal ; Delanghe, Joris ; Everaert, Karel ; Roggeman, Saskia

England: Taylor & Francis

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