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Chronic Intranasal Oxytocin Causes Long-Term Impairments in Partner Preference Formation in Male Prairie Voles

Bales, Karen L ; Perkeybile, Allison M ; Conley, Olivia G ; Lee, Meredith H ; Guoynes, Caleigh D ; Downing, Griffin M ; Yun, Catherine R ; Solomon, Marjorie ; Jacob, Suma ; Mendoza, Sally P

Biological psychiatry (1969), 2013-08, Vol.74 (3), p.180-188 [Periódico revisado por pares]

New York, NY: Elsevier Inc

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Título:
Chronic Intranasal Oxytocin Causes Long-Term Impairments in Partner Preference Formation in Male Prairie Voles
Autor: Bales, Karen L ; Perkeybile, Allison M ; Conley, Olivia G ; Lee, Meredith H ; Guoynes, Caleigh D ; Downing, Griffin M ; Yun, Catherine R ; Solomon, Marjorie ; Jacob, Suma ; Mendoza, Sally P
Assuntos: Administration, Intranasal ; Adult and adolescent clinical studies ; Age Factors ; Analysis of Variance ; Animals ; Animals, Newborn ; Arvicolinae ; Autism ; Biological and medical sciences ; Child clinical studies ; Developmental disorders ; Dose-Response Relationship, Drug ; Exploratory Behavior - drug effects ; Female ; Infantile autism ; intranasal ; Male ; Maze Learning - drug effects ; Medical sciences ; Models, Animal ; oxytocin ; Oxytocin - adverse effects ; Pair Bond ; Psychiatry ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. Psychiatry ; Psychoses ; Schizophrenia ; Sex Characteristics ; Sexual Behavior, Animal - drug effects ; social behavior ; Social Behavior Disorders - chemically induced ; Time Factors ; vasopressin
É parte de: Biological psychiatry (1969), 2013-08, Vol.74 (3), p.180-188
Descrição: Background Oxytocin (OT) is a hormone shown to be involved in social bonding in animal models. Intranasal OT is currently in clinical trials for use in disorders such as autism and schizophrenia. We examined long-term effects of intranasal OT given developmentally in the prairie vole ( Microtus ochrogaster ), a socially monogamous rodent, often used as an animal model to screen drugs that have therapeutic potential for social disorders. Methods We treated voles with one of three dosages of intranasal OT, or saline, from day 21 (weaning) through day 42 (sexual maturity). We examined both social behavior immediately following administration, as well as long-term changes in social and anxiety behavior after treatment ceased. Group sizes varied from 8 to 15 voles ( n = 89 voles total). Results Treatment with OT resulted in acute increases in social behavior in male voles with familiar partners, as seen in humans. However, long-term developmental treatment with low doses of intranasal OT resulted in a deficit in partner preference behavior (a reduction of contact with a familiar opposite-sex partner, used to index pair-bond formation) by male voles. Conclusions Long-term developmental treatment with OT may show results different to those predicted by short-term studies, as well as significant sex differences and dosage effects. Further animal study is crucial to determining safe and effective strategies for use of chronic intranasal OT, especially during development.
Editor: New York, NY: Elsevier Inc
Idioma: Inglês

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Chronic Intranasal Oxytocin Causes Long-Term Impairments in Partner Preference Formation in Male Prairie Voles

Bales, Karen L ; Perkeybile, Allison M ; Conley, Olivia G ; Lee, Meredith H ; Guoynes, Caleigh D ; Downing, Griffin M ; Yun, Catherine R ; Solomon, Marjorie ; Jacob, Suma ; Mendoza, Sally P

New York, NY: Elsevier Inc

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