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genome sequence of Bifidobacterium longum subsp. infantis reveals adaptations for milk utilization within the infant microbiome

Sela, D.A ; Chapman, J ; Adeuya, A ; Kim, J.H ; Chen, F ; Whitehead, T.R ; Lapidus, A ; Rokhsar, D.S ; Lebrilla, C.B ; German, J.B ; Price, N.P ; Richardson, P.M ; Mills, D.A

Proceedings of the National Academy of Sciences - PNAS, 2008-12, Vol.105 (48), p.18964-18969 [Periódico revisado por pares]

United States: National Academy of Sciences

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Título:
genome sequence of Bifidobacterium longum subsp. infantis reveals adaptations for milk utilization within the infant microbiome
Autor: Sela, D.A ; Chapman, J ; Adeuya, A ; Kim, J.H ; Chen, F ; Whitehead, T.R ; Lapidus, A ; Rokhsar, D.S ; Lebrilla, C.B ; German, J.B ; Price, N.P ; Richardson, P.M ; Mills, D.A
Assuntos: ATP binding cassette transporters ; Babies ; Bacteria ; Bacterial Proteins - classification ; Bacterial Proteins - genetics ; Bacterial Proteins - metabolism ; Bifidobacterium ; Bifidobacterium - genetics ; Bifidobacterium - metabolism ; Bifidobacterium longum ; Bifidobacterium longum subsp. infantis ; Biological Sciences ; Breast Feeding ; breast milk ; Breastfeeding & lactation ; carbohydrate metabolism ; Fatty acids ; Female ; Gastrointestinal tract ; Gastrointestinal Tract - microbiology ; Genes ; genome ; Genome, Bacterial ; Genomes ; Genomics ; Humans ; Infant, Newborn ; Infants ; intestinal microorganisms ; metabolism ; metabolomics ; Microbiota ; Milk ; Milk, Human - chemistry ; Milk, Human - metabolism ; Molecular Sequence Data ; Molecules ; Multigene Family ; Oligosaccharides ; Oligosaccharides - chemistry ; Oligosaccharides - metabolism ; Phylogeny ; Pregnancy ; proteomics
É parte de: Proceedings of the National Academy of Sciences - PNAS, 2008-12, Vol.105 (48), p.18964-18969
Notas: http://hdl.handle.net/10113/22027
http://dx.doi.org/10.1073/pnas.0809584105
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content type line 23
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USDOE Office of Science (SC), Biological and Environmental Research (BER)
Communicated by Todd R. Klaenhammer, North Carolina State University, Raleigh, NC, September 25, 2008
1Present address: Progentech, Emeryville, CA 95119.
Author contributions: D.A.S., D.S.R., C.B.L., J.B.G., N.P.P., P.M.R., and D.A.M. designed research; D.A.S., J.C., A.A., J.H.K., F.C., T.R.W., and A.L. performed research; D.A.S., J.C., A.A., J.H.K., A.L., N.P.P., P.M.R., and D.A.M. analyzed data; and D.A.S. and D.A.M. wrote the paper.
Descrição: Following birth, the breast-fed infant gastrointestinal tract is rapidly colonized by a microbial consortium often dominated by bifidobacteria. Accordingly, the complete genome sequence of Bifidobacterium longum subsp. infantis ATCC15697 reflects a competitive nutrient-utilization strategy targeting milk-borne molecules which lack a nutritive value to the neonate. Several chromosomal loci reflect potential adaptation to the infant host including a 43 kbp cluster encoding catabolic genes, extracellular solute binding proteins and permeases predicted to be active on milk oligosaccharides. An examination of in vivo metabolism has detected the hallmarks of milk oligosaccharide utilization via the central fermentative pathway using metabolomic and proteomic approaches. Finally, conservation of gene clusters in multiple isolates corroborates the genomic mechanism underlying milk utilization for this infant-associated phylotype.
Editor: United States: National Academy of Sciences
Idioma: Inglês

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genome sequence of Bifidobacterium longum subsp. infantis reveals adaptations for milk utilization within the infant microbiome

Sela, D.A ; Chapman, J ; Adeuya, A ; Kim, J.H ; Chen, F ; Whitehead, T.R ; Lapidus, A ; Rokhsar, D.S ; Lebrilla, C.B ; German, J.B ; Price, N.P ; Richardson, P.M ; Mills, D.A

United States: National Academy of Sciences

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