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Assessment of biomarkers of cardiovascular risk among HIV type 1-infected adolescents: role of soluble vascular cell adhesion molecule as an early indicator of endothelial inflammation

Syed, Salma S ; Balluz, Rula S ; Kabagambe, Edmond K ; Meyer, 3rd, William A ; Lukas, Susan ; Wilson, Craig M ; Kapogiannis, Bill G ; Nachman, Sharon A ; Sleasman, John W

AIDS research and human retroviruses, 2013-03, Vol.29 (3), p.493-500 [Periódico revisado por pares]

United States: Mary Ann Liebert, Inc

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  • Título:
    Assessment of biomarkers of cardiovascular risk among HIV type 1-infected adolescents: role of soluble vascular cell adhesion molecule as an early indicator of endothelial inflammation
  • Autor: Syed, Salma S ; Balluz, Rula S ; Kabagambe, Edmond K ; Meyer, 3rd, William A ; Lukas, Susan ; Wilson, Craig M ; Kapogiannis, Bill G ; Nachman, Sharon A ; Sleasman, John W
  • Assuntos: Adolescent ; AIDS/HIV ; Biomarkers - blood ; Cardiovascular Diseases - diagnosis ; Cohort Studies ; Endothelium, Vascular - pathology ; Female ; HIV Infections - complications ; HIV Infections - virology ; HIV-1 - pathogenicity ; Human immunodeficiency virus ; Humans ; Immunology ; Longitudinal Studies ; Male ; Retrovirus ; Vascular Cell Adhesion Molecule-1 - blood
  • É parte de: AIDS research and human retroviruses, 2013-03, Vol.29 (3), p.493-500
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  • Descrição: Cardiovascular disease (CVD) biomarkers were examined in a cohort of HIV-infected and HIV-uninfected adolescents who participated in Adolescent Trials Network study 083 utilizing samples from the Reaching for Excellence in Adolescent Care cohort, a longitudinal study of youth infected through adult risk behavior. Nonfasting blood samples from 97 HIV-infected and 81 HIV-uninfected adolescents infected by adult risk behaviors were analyzed for total cholesterol, low-density lipoprotein (LDL), high-density lipoprotein (HDL), very low-density lipoprotein (VLDL), triglycerides, apolipoprotein A-I, high-sensitivity C-reactive protein (hsCRP), soluble vascular adhesion molecule-1 (sVCAM-1), myeloperoxidase, and neopterin at baseline and 18 months later. Results were analyzed using ANOVA, Wilcoxon signed-rank, and paired t tests. Among infected subjects 67 received antiretroviral therapy and 30 were treatment naive. The HIV-infected and HIV-uninfected subjects were similar in gender, ethnicity, and cardiovascular risk factors such as smoking and obesity. In all groups lipid parameters were within accepted guidelines for cardiovascular risk. Among HIV-infected youth on antiretroviral therapy (ART), HDL and apoprotein A-I were significantly lower when compared to uninfected youth. hsCRP was not elevated and thus not predictive for risk in any group. sVCAM-1 levels were significantly elevated in both HIV-infected groups: 1,435 ng/ml and 1,492 ng/ml in untreated and treated subjects, respectively, and 1,064 ng/ml in the uninfected group (p<0.0001). Across all groups neopterin correlated with sVCAM at 18 months (Spearman correlation coefficient 0.58, p<0.0001). Only 9% of ART-treated subjects fully suppressed virus. Lipid profiles and hsCRP, traditional markers of cardiovascular disease, are not abnormal among HIV-infected youth but elevated sVCAM may be an early marker of atherosclerosis.
  • Editor: United States: Mary Ann Liebert, Inc
  • Idioma: Inglês
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  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

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