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A comparison of the demographics, clinical features, and survival of patients with adenoid cystic carcinoma of major and minor salivary glands versus less common sites within the Surveillance, Epidemiology, and End Results registry

Li, Nan ; Xu, Li ; Zhao, Hui ; El‐Naggar, Adel K. ; Sturgis, Erich M.

Cancer, 2012-08, Vol.118 (16), p.3945-3953 [Periódico revisado por pares]

Hoboken: Wiley Subscription Services, Inc., A Wiley Company

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Título:
A comparison of the demographics, clinical features, and survival of patients with adenoid cystic carcinoma of major and minor salivary glands versus less common sites within the Surveillance, Epidemiology, and End Results registry
Autor: Li, Nan ; Xu, Li ; Zhao, Hui ; El‐Naggar, Adel K. ; Sturgis, Erich M.
Assuntos: adenoid cystic carcinoma ; Age Factors ; Biological and medical sciences ; Breast Neoplasms - epidemiology ; Breast Neoplasms - mortality ; Carcinoma, Adenoid Cystic - diagnosis ; Carcinoma, Adenoid Cystic - epidemiology ; Carcinoma, Adenoid Cystic - mortality ; epidemiology ; Eye Neoplasms ; Female ; Genital Neoplasms, Female - epidemiology ; Genital Neoplasms, Female - mortality ; Humans ; Lung Neoplasms - epidemiology ; Lung Neoplasms - mortality ; Male ; Medical sciences ; Middle Aged ; Mouth Neoplasms - epidemiology ; Mouth Neoplasms - mortality ; Prognosis ; Salivary Gland Neoplasms - diagnosis ; Salivary Gland Neoplasms - epidemiology ; Salivary Gland Neoplasms - mortality ; Salivary Glands, Minor ; Sex Factors ; site ; Skin Neoplasms - epidemiology ; Skin Neoplasms - mortality ; Surveillance, Epidemiology, and End Results ; survival ; Tumors
É parte de: Cancer, 2012-08, Vol.118 (16), p.3945-3953
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Descrição: BACKGROUND: The scientific literature to date lacks population‐based studies on the demographics, clinical features, and survival of patients with adenoid cystic carcinoma (ACC) of different anatomic sites. METHODS: The authors identified 5349 patients who had ACC of the major salivary glands (N = 1850), minor salivary glands (N = 2077), breast (N = 696), skin (N = 291), lung and bronchus (N = 203), female genital system (N = 132), and eye and orbit (N = 100) from the Surveillance, Epidemiology, and End Results (SEER) registry. Differences in demographics, clinical features, and survival of patients were assessed. RESULTS: ACC of the eye and orbit was associated with younger age at presentation (mean age,49.9 years). ACC of the skin or breast tended to present with less aggressive prognostic features, whereas ACC of the lung and bronchus or eye and orbit tended to present with more aggressive prognostic features. In a multivariate survival analysis of patients who presented with localized disease, patients with ACC of the breast (hazard ratio [HR], 0.40) or skin (HR, 0.40) had a significantly lower risk death than patients with ACC of the major salivary glands; whereas patients with ACC of the lung and bronchus (HR, 3.72) or the eye and orbit (HR, 3.67) had a significantly higher risk. For patients who presented with regional disease, the only clear prognostic difference in multivariate analysis was that patients with ACC of skin fared significantly better. CONCLUSIONS: The demographics and clinical features of patients with ACC differ by disease site. The current results indicated that site may be an important predictor of survival for patients who present with localized disease but is less important for patients who present with regional disease. Cancer 2012. © 2011 American Cancer Society. The demographics and clinical features of adenoid cystic carcinoma differ by disease site. Anatomic site may be an important predictor of survival for patients who present with localized disease but is less important for patients who present with regional disease.
Editor: Hoboken: Wiley Subscription Services, Inc., A Wiley Company
Idioma: Inglês

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A comparison of the demographics, clinical features, and survival of patients with adenoid cystic carcinoma of major and minor salivary glands versus less common sites within the Surveillance, Epidemiology, and End Results registry

Li, Nan ; Xu, Li ; Zhao, Hui ; El‐Naggar, Adel K. ; Sturgis, Erich M.

Hoboken: Wiley Subscription Services, Inc., A Wiley Company

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