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Serotype-specific differences in inhibition of reovirus infectivity by human-milk glycans are determined by viral attachment protein σ1

Iskarpatyoti, Jason A ; Morse, E. Ashley ; Paul McClung, R ; Ikizler, Miné ; Wetzel, J. Denise ; Contractor, Nikhat ; Dermody, Terence S

Virology (New York, N.Y.), 2012-11, Vol.433 (2), p.489-497 [Periódico revisado por pares]

United States: Elsevier Inc

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Título:
Serotype-specific differences in inhibition of reovirus infectivity by human-milk glycans are determined by viral attachment protein σ1
Autor: Iskarpatyoti, Jason A ; Morse, E. Ashley ; Paul McClung, R ; Ikizler, Miné ; Wetzel, J. Denise ; Contractor, Nikhat ; Dermody, Terence S
Assuntos: Animals ; Capsid Proteins - genetics ; Capsid Proteins - immunology ; Cattle ; Female ; G(M3) Ganglioside - immunology ; Gangliosides ; Gangliosides - immunology ; Genes, Viral ; Glucocerebroside ; HeLa Cells ; Hemagglutination Inhibition Tests ; Host-Pathogen Interactions - immunology ; Human milk components ; Humans ; Infectious Disease ; L Cells (Cell Line) ; Mammalian orthoreovirus 3 - classification ; Mammalian orthoreovirus 3 - genetics ; Mammalian orthoreovirus 3 - immunology ; Mammalian orthoreovirus 3 - pathogenicity ; Mice ; Milk, Human - immunology ; Milk, Human - virology ; Oligosaccharides - immunology ; Orthoreovirus, Mammalian - classification ; Orthoreovirus, Mammalian - genetics ; Orthoreovirus, Mammalian - immunology ; Orthoreovirus, Mammalian - pathogenicity ; Polysaccharides - immunology ; Reoviridae Infections - immunology ; Reoviridae Infections - prevention & control ; Reoviridae Infections - virology ; Reovirus ; Serotyping ; Sialyllactose ; Species Specificity ; Virus Attachment
É parte de: Virology (New York, N.Y.), 2012-11, Vol.433 (2), p.489-497
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
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Descrição: Abstract Human milk contains many bioactive components, including secretory IgA, oligosaccharides, and milk-associated proteins. We assessed the antiviral effects of several components of milk against mammalian reoviruses. We found that glucocerebroside (GCB) inhibited the infectivity of reovirus strain type 1 Lang (T1L), whereas gangliosides GD3 and GM3 and 3′-sialyllactose (3SL) inhibited the infectivity of reovirus strain type 3 Dearing (T3D). Agglutination of erythrocytes mediated by T1L and T3D was inhibited by GD3, GM3, and bovine lactoferrin. Additionally, α-sialic acid, 3SL, 6′-sialyllactose, sialic acid, human lactoferrin, osteopontin, and α-lactalbumin inhibited hemagglutination mediated by T3D. Using single-gene reassortant viruses, we found that serotype-specific differences segregate with the gene encoding the viral attachment protein. Furthermore, GD3, GM3, and 3SL inhibit T3D infectivity by blocking binding to host cells, whereas GCB inhibits T1L infectivity post-attachment. These results enhance an understanding of reovirus cell attachment and define a mechanism for the antimicrobial activity of human milk.
Editor: United States: Elsevier Inc
Idioma: Inglês

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Serotype-specific differences in inhibition of reovirus infectivity by human-milk glycans are determined by viral attachment protein σ1

Iskarpatyoti, Jason A ; Morse, E. Ashley ; Paul McClung, R ; Ikizler, Miné ; Wetzel, J. Denise ; Contractor, Nikhat ; Dermody, Terence S

United States: Elsevier Inc

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