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Fonsecaea pedrosoi Conidia Induces Activation of Dendritic Cells and Increases CD11c+ Cells in Regional Lymph Nodes During Experimental Chromoblastomycosis

Kimura, Telma Fátima Emidio ; Romera, Lavínia Maria Dal’Mas ; de Almeida, Sandro Rogério

Mycopathologia (1975), 2020-04, Vol.185 (2), p.245-256 [Periódico revisado por pares]

Dordrecht: Springer Netherlands

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Título:
Fonsecaea pedrosoi Conidia Induces Activation of Dendritic Cells and Increases CD11c+ Cells in Regional Lymph Nodes During Experimental Chromoblastomycosis
Autor: Kimura, Telma Fátima Emidio ; Romera, Lavínia Maria Dal’Mas ; de Almeida, Sandro Rogério
Assuntos: Animals ; Antigens ; Ascomycota - immunology ; Ascomycota - pathogenicity ; Biomedical and Life Sciences ; CD11c antigen ; CD11c Antigen - metabolism ; Cell activation ; Cell Movement ; Chromoblastomycosis - immunology ; Chromomycosis ; Conidia ; Dendritic cells ; Dendritic Cells - metabolism ; Eukaryotic Microbiology ; Fonsecaea - immunology ; Fonsecaea - pathogenicity ; Fonsecaea pedrosoi ; Fungal infections ; Leukocyte migration ; Life Sciences ; Lymph Nodes ; Lymphatic system ; Lymphocytes T ; Medical Microbiology ; Mice ; Mice, Inbred BALB C ; Microbial Ecology ; Microbiology ; Morbidity ; Mycosis ; Original Article ; Phagocytes ; Phagocytosis ; Phenotypes ; Plant Sciences ; Spores, Fungal - immunology ; Surface markers
É parte de: Mycopathologia (1975), 2020-04, Vol.185 (2), p.245-256
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SourceType-Scholarly Journals-1
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Descrição: The chromoblastomycosis is a subcutaneous mycosis with a high morbidity rate, Fonsecaea pedrosoi being the largest etiologic agent of this mycosis, usually confined to the skin and subcutaneous tissues. Rarely people get the cure, because the therapies shown to be deficient and few studies report the host–parasite relationship. Dendritic cells (DCs) are specialized in presenting antigens to naïve T lymphocytes inducing primary immune responses. Therefore, we propose to study the migratory capacity of DCs after infection with conidia of F. pedrosoi . The phenotype of DCs was evaluated using cells obtained from footpad and lymph nodes of BALB/c mice after 12, 24 and 72 h of infection. After 24 and 72 h of infection, we found a significant decrease in DCs in footpad and a significant increase in the lymph nodes after 72 h. The expression of surface markers and co-stimulatory molecules were reduced in cells obtained from footpad. To better assess the migratory capacity of DCs migration from footpad, CFSE-stained conidia were injected subcutaneously. We found that after 12 and 72 h, CD11c + cells were increased in regional lymph nodes, leading us to believe that DCs (CD11c + ) were able to phagocytic conidia present in footpad and migrated to regional lymph nodes.
Editor: Dordrecht: Springer Netherlands
Idioma: Inglês

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Fonsecaea pedrosoi Conidia Induces Activation of Dendritic Cells and Increases CD11c+ Cells in Regional Lymph Nodes During Experimental Chromoblastomycosis

Kimura, Telma Fátima Emidio ; Romera, Lavínia Maria Dal’Mas ; de Almeida, Sandro Rogério

Dordrecht: Springer Netherlands

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