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ORF8/ORF8a: a difference between SARS-CoV-2 and SARS-CoV

Zandi, Milad

The European respiratory journal, 2022-02, Vol.59 (2), p.2102818 [Periódico revisado por pares]

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Título:
ORF8/ORF8a: a difference between SARS-CoV-2 and SARS-CoV
Autor: Zandi, Milad
Assuntos: Agora ; Biomarkers ; COVID-19 ; Humans ; Phylogeny ; SARS-CoV-2
É parte de: The European respiratory journal, 2022-02, Vol.59 (2), p.2102818
Notas: SourceType-Other Sources-1
content type line 63
ObjectType-Correspondence-1
ObjectType-Commentary-2
Descrição: Recently in an editorial published as an “early view” paper in the European Respiratory Journal , Hartsell et al . [1] reported that ORF8a has a role in SARS-CoV-2 infection. In figure 1, it was stated that ORF7a, ORF8a and ORF9b locate within the mitochondria and can inhibit RIG1-MAVS (retinoic acid-inducible gene I-mitochondrial antiviral signalling protein)-dependent interferon signalling, enhance viral replication and disrupt mitochondrial function [1], although based on scientific evidence, SARS-CoV-2 lacks ORF8a [2–4]. ORF8 as an accessory protein of SARS-CoV-2 https://bit.ly/3Gr3OTK
Editor: England: European Respiratory Society
Idioma: Inglês

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