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Partial liquid ventilation reduces fluid filtration of Isolated rabbit lungs with acute Hydrochloric acid-induced edema

LOER, Stephan A ; TARNOW, Jörg

Anesthesiology (Philadelphia), 2001-06, Vol.94 (6), p.1045-1049 [Periódico revisado por pares]

Hagerstown, MD: Lippincott

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  • Título:
    Partial liquid ventilation reduces fluid filtration of Isolated rabbit lungs with acute Hydrochloric acid-induced edema
  • Autor: LOER, Stephan A ; TARNOW, Jörg
  • Assuntos: Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; Animals ; Biological and medical sciences ; Blood Pressure - physiology ; Capillary Permeability - physiology ; Emergency and intensive respiratory care ; Female ; Filtration ; Fluorocarbons ; Hydrochloric Acid ; In Vitro Techniques ; Intensive care medicine ; Liquid Ventilation ; Lung - physiopathology ; Male ; Medical sciences ; Pulmonary Edema - chemically induced ; Pulmonary Edema - physiopathology ; Rabbits
  • É parte de: Anesthesiology (Philadelphia), 2001-06, Vol.94 (6), p.1045-1049
  • Descrição: Hydrochloric acid aspiration increases pulmonary microvascular permeability. The authors tested the hypothesis that partial liquid ventilation has a beneficial effect on filtration coefficients in acute acid-induced lung injury. Isolated blood-perfused rabbit lungs were assigned randomly to one of four groups. Group 1 (n = 6) served as a control group without edema. In group 2 (n = 6), group 3 (n = 6), and group 4 (n = 6), pulmonary edema was induced by intratracheal instillation of hydrochloric acid (0.1 N, 2 ml/kg body weight). Filtration coefficients were determined 30 min after this injury (by measuring loss of perfusate after increase of left atrial pressure). Group 2 lungs were gas ventilated, and group 3 lungs received partial liquid ventilation (15 ml perfluorocarbon/kg body weight). In group 4 lungs, the authors studied the immediate effects of bronchial perfluorocarbon instillation on ongoing filtration. Intratracheal instillation of hydrochloric acid markedly increased filtration coefficients when compared with non-injured control lungs (2.3 +/- 0.7 vs. 0.31 +/- 0.08 ml.min(-1). mmHg(-1).100 g(-1) wet lung weight, P < 0.01). Partial liquid ventilation reduced filtration coefficients of the injured lungs (to 0.9 +/- 0.3 ml.min(-1).mmHg(-1).100 g(-1) wet lung weight, P = 0.022). Neither pulmonary artery nor capillary pressures (determined by simultaneous occlusion of inflow and outflow of the pulmonary circulation) were changed by hydrochloric acid instillation or by partial liquid ventilation. During ongoing filtration, bronchial perfluorocarbon instillation (5 ml/kg body weight) immediately reduced the amount of filtered fluid by approximately 50% (P = 0.027). In the acute phase after acid injury, partial liquid ventilation reduced pathologic fluid filtration. This effect started immediately after bronchial perfluorocarbon instillation and was not associated with changes in mean pulmonary artery, capillary, or airway pressures. The authors suggest that in the early phase of acid injury, reduction of fluid filtration contributes to the beneficial effects of partial liquid ventilation on gas exchange and lung mechanics.
  • Editor: Hagerstown, MD: Lippincott
  • Idioma: Inglês
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  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

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