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Chlamydia trachomatis Pgp3 Antibody Population Seroprevalence before and during an Era of Widespread Opportunistic Chlamydia Screening in England (1994-2012)

Woodhall, Sarah C ; Wills, Gillian S ; Horner, Patrick J ; Craig, Rachel ; Mindell, Jennifer S ; Murphy, Gary ; McClure, Myra O ; Soldan, Kate ; Nardone, Anthony ; Johnson, Anne M Zhong, Guangming

PloS one, 2017-01, Vol.12 (1), p.e0152810-e0152810 [Periódico revisado por pares]

United States: Public Library of Science

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Chlamydia trachomatis Pgp3 Antibody Population Seroprevalence before and during an Era of Widespread Opportunistic Chlamydia Screening in England (1994-2012)
Autor: Woodhall, Sarah C ; Wills, Gillian S ; Horner, Patrick J ; Craig, Rachel ; Mindell, Jennifer S ; Murphy, Gary ; McClure, Myra O ; Soldan, Kate ; Nardone, Anthony ; Johnson, Anne M
Zhong, Guangming
Assuntos: Adolescent ; Adult ; Age ; Age Factors ; Analysis ; Antibodies ; Antibodies, Bacterial - genetics ; Antibodies, Bacterial - immunology ; Antibodies, Bacterial - isolation & purification ; Antigens, Bacterial - genetics ; Antigens, Bacterial - immunology ; Antigens, Bacterial - isolation & purification ; Attitudes ; Bacteria ; Bacterial Proteins - genetics ; Bacterial Proteins - immunology ; Bacterial Proteins - isolation & purification ; Biology and Life Sciences ; Chlamydia ; Chlamydia infections ; Chlamydia Infections - epidemiology ; Chlamydia Infections - genetics ; Chlamydia Infections - transmission ; Chlamydia trachomatis ; Chlamydia trachomatis - genetics ; Chlamydia trachomatis - isolation & purification ; Chlamydia trachomatis - pathogenicity ; College campuses ; Condoms ; Diagnosis ; England - epidemiology ; Enzyme-Linked Immunosorbent Assay ; Female ; Health aspects ; Health risks ; Humans ; Immunoassays ; Immunoglobulins ; Incidence ; Infections ; Laboratories ; Lifestyles ; Male ; Medical research ; Medicine and Health Sciences ; Men ; Mens health ; Opportunistic Infections - epidemiology ; Opportunistic Infections - genetics ; Opportunistic Infections - transmission ; Outcome and process assessment (Health Care) ; Outcome and process assessment (Medical care) ; People and Places ; Polls & surveys ; Population ; Population studies ; Prevention ; Public health ; Research and Analysis Methods ; Risk Factors ; Screening ; Seroepidemiologic Studies ; Serology ; Sex ; Sexual Behavior ; Sexual Partners ; Sexually transmitted diseases ; STD ; Studies ; Trends ; Vaccines ; Viral antibodies ; Womens health ; Young Adult
É parte de: PloS one, 2017-01, Vol.12 (1), p.e0152810-e0152810
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
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Competing Interests: SCW, AN and GM are employed by Public Health England. This does not alter our adherence to PLOS ONE policies on sharing data and materials.
Conceived and designed the experiments: AMJ AN SW KS PH MM GW.Performed the experiments: GW.Analyzed the data: SW.Contributed reagents/materials/analysis tools: MM GW GM RC JSM.Wrote the paper: SW GW PH RC JSM GM MM KS AN AMJ.Provided access to, and expert advice on analysis of, the Health Survey for England: RC JSM. Managed specimen storage: GM.
These authors also contributed equally to this work.
Descrição: Opportunistic chlamydia screening of <25 year-olds was nationally-implemented in England in 2008 but its impact on chlamydia transmission is poorly understood. We undertook a population-based seroprevalence study to explore the impact of screening on cumulative incidence of chlamydia, as measured by C.trachomatis-specific antibody. Anonymised sera from participants in the nationally-representative Health Surveys for England (HSE) were tested for C.trachomatis antibodies using two novel Pgp3 enzyme-linked immunosorbent assays (ELISAs) as a marker of past infection. Determinants of being seropositive were explored using logistic regression among 16-44 year-old women and men in 2010 and 2012 (years when sexual behaviour questions were included in the survey) (n = 1,402 women; 1,119 men). Seroprevalence trends among 16-24 year-old women (n = 3,361) were investigated over ten time points from 1994-2012. In HSE2010/2012, Pgp3 seroprevalence among 16-44 year-olds was 24.4% (95%CI 22.0-27.1) in women and 13.9% (11.8-16.2) in men. Seroprevalence increased with age (up to 33.5% [27.5-40.2] in 30-34 year-old women, 18.7% [13.4-25.6] in 35-39 year-old men); years since first sex; number of lifetime sexual partners; and younger age at first sex. 76.7% of seropositive 16-24 year-olds had never been diagnosed with chlamydia. Among 16-24 year-old women, a non-significant decline in seroprevalence was observed from 2008-2012 (prevalence ratio per year: 0.94 [0.84-1.05]). Our application of Pgp3 ELISAs demonstrates a high lifetime risk of chlamydia infection among women and a large proportion of undiagnosed infections. A decrease in age-specific cumulative incidence following national implementation of opportunistic chlamydia screening has not yet been demonstrated. We propose these assays be used to assess impact of chlamydia control programmes.
Editor: United States: Public Library of Science
Idioma: Inglês

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Chlamydia trachomatis Pgp3 Antibody Population Seroprevalence before and during an Era of Widespread Opportunistic Chlamydia Screening in England (1994-2012)

Woodhall, Sarah C ; Wills, Gillian S ; Horner, Patrick J ; Craig, Rachel ; Mindell, Jennifer S ; Murphy, Gary ; McClure, Myra O ; Soldan, Kate ; Nardone, Anthony ; Johnson, Anne M Zhong, Guangming

United States: Public Library of Science

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