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Trial of Early, Goal-Directed Resuscitation for Septic Shock

Mouncey, Paul R ; Osborn, Tiffany M ; Power, G. Sarah ; Harrison, David A ; Sadique, M. Zia ; Grieve, Richard D ; Jahan, Rahi ; Harvey, Sheila E ; Bell, Derek ; Bion, Julian F ; Coats, Timothy J ; Singer, Mervyn ; Young, J. Duncan ; Rowan, Kathryn M

The New England journal of medicine, 2015-04, Vol.372 (14), p.1301-1311 [Periódico revisado por pares]

United States: Massachusetts Medical Society

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Título:
Trial of Early, Goal-Directed Resuscitation for Septic Shock
Autor: Mouncey, Paul R ; Osborn, Tiffany M ; Power, G. Sarah ; Harrison, David A ; Sadique, M. Zia ; Grieve, Richard D ; Jahan, Rahi ; Harvey, Sheila E ; Bell, Derek ; Bion, Julian F ; Coats, Timothy J ; Singer, Mervyn ; Young, J. Duncan ; Rowan, Kathryn M
Assuntos: Adult ; Aged ; Anti-Bacterial Agents - therapeutic use ; Antibiotics ; Blood Transfusion ; Care and treatment ; Clinical Protocols ; Clinical trials ; Combined Modality Therapy ; Cost-Benefit Analysis ; Female ; Fluid Therapy ; Humans ; Infusions, Intravenous ; Intravenous administration ; Kaplan-Meier Estimate ; Male ; Medical research ; Medical treatment ; Methods ; Middle Aged ; Mortality ; Patient outcomes ; Patients ; Practice guidelines (Medicine) ; Practice Guidelines as Topic ; Quality of Life ; Quality-Adjusted Life Years ; Resuscitation ; Resuscitation - economics ; Resuscitation - methods ; Sepsis ; Septic shock ; Shock, Septic - mortality ; Shock, Septic - therapy ; Vasoactive agents ; Vasoconstrictor Agents - therapeutic use
É parte de: The New England journal of medicine, 2015-04, Vol.372 (14), p.1301-1311
Notas: ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-News-3
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Descrição: The management of sepsis has substantially improved over the past 15 years. In this study, early, goal-directed therapy, which focuses on the initial resuscitation efforts, was compared with usual care for the management of severe sepsis in the United Kingdom. The incidence of severe sepsis and septic shock in adults is estimated to range from 56 to 91 per 100,000 population per year. 1 Affected patients have high rates of death, complications, and resource utilization. 2 – 5 Since 2002, the Surviving Sepsis Campaign (SSC) has promoted best practice, including early recognition, source control, appropriate and timely antibiotic administration, and resuscitation with intravenous fluids and vasoactive drugs. 6 – 8 Resuscitation guidance is largely based on a 2001 single-center, proof-of-concept study by Rivers et al., which indicated that protocolized delivery of 6 hours of early, goal-directed therapy (EGDT) to patients presenting to the emergency department . . .
Editor: United States: Massachusetts Medical Society
Idioma: Inglês

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Trial of Early, Goal-Directed Resuscitation for Septic Shock

Mouncey, Paul R ; Osborn, Tiffany M ; Power, G. Sarah ; Harrison, David A ; Sadique, M. Zia ; Grieve, Richard D ; Jahan, Rahi ; Harvey, Sheila E ; Bell, Derek ; Bion, Julian F ; Coats, Timothy J ; Singer, Mervyn ; Young, J. Duncan ; Rowan, Kathryn M

United States: Massachusetts Medical Society

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