Idioma:

MDR-1 and MRP-1 activity in peripheral blood leukocytes of rheumatoid arthritis patients

Micsik, Tamás ; Lőrincz, András ; Gál, János ; Schwab, Richard ; Peták, István

Diagnostic pathology, 2015-12, Vol.10 (1), p.216-216, Article 216 [Periódico revisado por pares]

England: BioMed Central

Texto completo disponível

Citações Citado por

Enviar para

Título:
MDR-1 and MRP-1 activity in peripheral blood leukocytes of rheumatoid arthritis patients
Autor: Micsik, Tamás ; Lőrincz, András ; Gál, János ; Schwab, Richard ; Peták, István
Assuntos: Antirheumatic Agents - metabolism ; Antirheumatic Agents - therapeutic use ; Arthritis, Rheumatoid - blood ; Arthritis, Rheumatoid - diagnosis ; Arthritis, Rheumatoid - drug therapy ; Arthritis, Rheumatoid - immunology ; ATP Binding Cassette Transporter, Sub-Family B - blood ; Biomarkers - blood ; Case-Control Studies ; Humans ; Leukocytes - drug effects ; Leukocytes - immunology ; Leukocytes - metabolism ; Methotrexate - metabolism ; Methotrexate - therapeutic use ; Multidrug Resistance-Associated Proteins - blood ; Remission Induction ; Treatment Outcome
É parte de: Diagnostic pathology, 2015-12, Vol.10 (1), p.216-216, Article 216
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Descrição: Rheumatoid Arthritis is a chronic disease leading to decreased quality of life with a rather variable response rate to Disease Modifying Anti Rheumatic Drugs. Methotrexate (MTX) is the gold standard therapy in Rheumatoid Arthritis. The Multidrug resistance Related Protein and Multi Drug Resistance protein 1, also called P-glycoprotein-170 transporters can alter the intracellular concentration of different drugs. Methotrexate is an MRP1 substrate and thus the functional activity of MRP1 might have a clinical impact on the efficiency of the Methotrexate-therapy in Rheumatoid Arthritis. We have compared the functional Multidrug Activity Factors (MAF) of the MDR1 and MRP1 transporters of Peripheral Blood Leukocytes of 59 Rheumatoid Arthritis patients with various response rate to MTX-therapy (MTX-responder, MTX-resistant and MTX-intolerant RA-groups) and 47 non-RA controls in six different leukocyte subpopulations (neutrophil leukocytes, monocytes, lymphocytes, CD4+, CD8+ and CD19+ cells). There was a decreased MAF of RA patients compared to non- Rheumatoid Arthritis patients and healthy controls in the leukocyte subpopulations. There was a significant difference between the MAF values of the MTX-responder and MTX intolerant groups. But we have not found significant differences between the MAF values of the MTX-responder and MTX-resistant Rheumatoid Arthritis -groups. Our results suggest that MDR1 and MRP1 functional activity does not seem to affect the response rate to MTX-therapy of Rheumatoid Arthritis-patients, but it might be useful in predicting MTX-side effects. We have demonstrated the decreased functional MDR-activity on almost 60 Rheumatoid Arthritis patients, which can be interpreted as a sign of the immune-suppressive effect of the MTX-treatment.
Editor: England: BioMed Central
Idioma: Inglês

Links

View this record in MEDLINE/PubMed

Voltar para lista de resultados

Realização: Logos de Redes Sociais:

MDR-1 and MRP-1 activity in peripheral blood leukocytes of rheumatoid arthritis patients

Micsik, Tamás ; Lőrincz, András ; Gál, János ; Schwab, Richard ; Peták, István

England: BioMed Central

Buscando em bases de dados remotas. Favor aguardar.