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Synergy of single-cell sequencing analyses and in vivo lineage-tracing approaches: A new opportunity for stem cell biology

Matsushita, Yuki ; Ono, Wanida ; Ono, Noriaki

Biocell, 2022, Vol.46 (5), p.1157-1162

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Título:
Synergy of single-cell sequencing analyses and in vivo lineage-tracing approaches: A new opportunity for stem cell biology
Autor: Matsushita, Yuki ; Ono, Wanida ; Ono, Noriaki
É parte de: Biocell, 2022, Vol.46 (5), p.1157-1162
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Author Contribution: The authors confirm contribution to the paper as follows: conception, design and draft manuscript preparation: YM and NO; Revising manuscript content: WO. All authors approved the final version of the manuscript.
Descrição: Single-cell sequencing technologies have rapidly progressed in recent years, and been applied to characterize stem cells in a number of organs. Somatic (postnatal) stem cells are generally identified using combinations of cell surface markers and transcription factors. However, it has been challenging to define micro-heterogeneity within "stem cell" populations, each of which stands at a different level of differentiation. As stem cells become defined at a single-cell level, their differentiation path becomes clearly defined. Here, this viewpoint discusses the potential synergy of single-cell sequencing analyses with lineage-tracing approaches, with an emphasis on practical considerations in stem cell biology.
Editor: United States
Idioma: Inglês

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