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Effects of ACTH-Pro-Gly-Pro Peptide on the Levels of Pro- and Anti-Inflammatory Cytokines in Wistar Rats under Conditions of Chronic Restraint Stress

Vorvul, A.O ; Bobyntsev, I.I ; Medvedeva, O.A ; Azarova, Yu.E

Bulletin of experimental biology and medicine, 2023-04, Vol.174 (6), p.716 [Periódico revisado por pares]

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Título:
Effects of ACTH-Pro-Gly-Pro Peptide on the Levels of Pro- and Anti-Inflammatory Cytokines in Wistar Rats under Conditions of Chronic Restraint Stress
Autor: Vorvul, A.O ; Bobyntsev, I.I ; Medvedeva, O.A ; Azarova, Yu.E
Assuntos: ACTH ; Anti-inflammatory drugs ; Glycine ; Inflammation ; Interleukins ; Peptides
É parte de: Bulletin of experimental biology and medicine, 2023-04, Vol.174 (6), p.716
Descrição: We evaluated the effect of [ACTH.sub.6-9]-Pro-Gly-Pro ([ACTH.sub.6-9]-PGP) peptide on the serum levels of pro- and anti-inflammatory cytokines in experimental animals under conditions of chronic restraint stress. Stress exposure over 2 weeks led to an increase in the levels of IL-1[beta], IL-6, and IFN[gamma] in rats. Daily intraperitoneal injection of [ACTH.sub.6-9]-PGP in a dose of 5 pg/kg before stress exposure significantly decreased the levels of IL-6 and IFN[gamma] by 4.8 and 49.3% respectively. Administration of the peptide in a dose of 50 [micro]g/kg decreased the levels of IL-1[beta] and IFN[gamma] by 51.2 and 39.7%, respectively. However, no changes in the cytokine levels were observed after injection of the peptide in a dose of 500 [micro]g/kg. Thus, [ACTH.sub.6-9]-PGP administered in doses of 5 and 50 [micro]g/kg prevented the stress-induced changes in the levels of pro- and inflammatory cytokines. Key Words: [ACTH.sub.6-9]-PGP; chronic restraint stress; interleukins; inflammation
Editor: Springer
Idioma: Inglês

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