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Identification of hepadnavirus in the sera of cats

Lanave, Gianvito ; Capozza, Paolo ; Diakoudi, Georgia ; Catella, Cristiana ; Catucci, Leonardo ; Ghergo, Paola ; Stasi, Fabio ; Barrs, Vanessa ; Beatty, Julia ; Decaro, Nicola ; Buonavoglia, Canio ; Martella, Vito ; Camero, Michele

Scientific reports, 2019-07, Vol.9 (1), p.10668-6, Article 10668 [Periódico revisado por pares]

England: Nature Publishing Group

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Título:
Identification of hepadnavirus in the sera of cats
Autor: Lanave, Gianvito ; Capozza, Paolo ; Diakoudi, Georgia ; Catella, Cristiana ; Catucci, Leonardo ; Ghergo, Paola ; Stasi, Fabio ; Barrs, Vanessa ; Beatty, Julia ; Decaro, Nicola ; Buonavoglia, Canio ; Martella, Vito ; Camero, Michele
Assuntos: Animals ; Cat Diseases - blood ; Cat Diseases - diagnosis ; Cats ; Cirrhosis ; Genome, Viral ; Genomes ; Hepadnaviridae - isolation & purification ; Hepadnaviridae Infections - blood ; Hepadnaviridae Infections - diagnosis ; Hepadnaviridae Infections - veterinary ; Hepatitis ; Hepatitis B ; Hepatocellular carcinoma ; Infectious diseases ; Liver diseases ; Lymphoma ; Viral Load
É parte de: Scientific reports, 2019-07, Vol.9 (1), p.10668-6, Article 10668
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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Descrição: Hepadnaviruses infect several animal species. The prototype species, human hepatitis B virus (HBV), increases the risk of liver diseases and may cause cirrhosis and hepatocellular carcinoma. Recently a novel hepadnavirus, similar to HBV, has been identified through transcriptomics studies in a domestic cat with large cell lymphoma in Australia. Herewith, a collection of 390 feline serum samples was screened for hepadnavirus. Overall, the virus was identified in 10.8% of the sera with a significantly higher prevalence (17.8%) in the sera of animals with a clinical suspect of infectious disease. Upon genome sequencing, the virus was closely related (97.0% nt identity) to the prototype Australian feline virus Sydney 2016. The mean and median values of hepadnavirus in the feline sera were 1.3 × 10 and 2.1 × 10 genome copies per mL (range 3.3 × 10 -2.5 × 10 genome copies per mL). For a subset of hepadnavirus-positive samples, information on the hemato-chemical parameters was available and in 10/20 animals a profile suggestive of liver damage was present. Also, in 7/10 animals with suspected hepatic disease, virus load was >10 genome copies per mL, i.e. above the threshold considered at risk of active hepatitis and liver damage for HBV.
Editor: England: Nature Publishing Group
Idioma: Inglês

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Identification of hepadnavirus in the sera of cats

Lanave, Gianvito ; Capozza, Paolo ; Diakoudi, Georgia ; Catella, Cristiana ; Catucci, Leonardo ; Ghergo, Paola ; Stasi, Fabio ; Barrs, Vanessa ; Beatty, Julia ; Decaro, Nicola ; Buonavoglia, Canio ; Martella, Vito ; Camero, Michele

England: Nature Publishing Group

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