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Parkin in cancer: Mitophagy-related/unrelated tasks

Eid, Nabil ; Kondo, Yoichi

World journal of hepatology, 2017-03, Vol.9 (7), p.349-351

United States: Baishideng Publishing Group Inc

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  • Título:
    Parkin in cancer: Mitophagy-related/unrelated tasks
  • Autor: Eid, Nabil ; Kondo, Yoichi
  • É parte de: World journal of hepatology, 2017-03, Vol.9 (7), p.349-351
  • Notas: Nabil Eid;Yoichi Kondo;Division of Life Sciences,Department of Anatomy and Cell Biology,Osaka Medical College
    SourceType-Other Sources-1
    content type line 63
    ObjectType-Editorial-2
    ObjectType-Commentary-1
    Author contributions: Eid N wrote the paper; Kondo Y critically reviewed it.
    Correspondence to: Dr. Nabil Eid, Junior Associate Professor, Division of Life Sciences, Department of Anatomy and Cell Biology, Osaka Medical College, 2-7 Daigaku-machi, Takatsuki, Osaka 569-8686, Japan. nabil@osaka-med.ac.jp
    Telephone: +81-72-6847197 Fax: +81-72-6846511
  • Descrição: Dysfunctional mitochondria may produce excessive reactive oxygen species, thus inducing DNA damage, which may be oncogenic if not repaired. As a major role of the PINK1-Parkin pathway involves selective autophagic clearance of damaged mitochondria via a process termed mitophagy, Parkin-mediated mitophagy may be a tumorsuppressive mechanism. As an alternative mechanism for tumor inhibition beyond mitophagy, Parkin has been reported to have other oncosuppressive functions such as DNA repair, negative regulation of cell proliferation and stimulation of p53 tumor suppressor function. The authors recently reported that acute ethanol-induced mitophagy in hepatocytes was associated with Parkin mitochondrial translocation and colocalization with accumulated 8-OHd G(a marker of DNA damage and mutagenicity). This finding suggests:(1) the possibility of Parkin-mediated repair of damaged mitochondrial DNA in hepatocytes of ethanol-treated rats(ETRs) as an oncosuppressive mechanism; and(2) potential induction of cytoprotective mitophagy in ETR hepatocytes if mitochondrial damage is too severe to be repaired. Below is a summary of the various roles Parkin plays in tumor suppression, which may or may not be related to mitophagy. A proper understanding of the various tasks performed by Parkin in tumorigenesis may help in cancer therapy by allowing the PINK1-Parkin pathway to be targeted.
  • Editor: United States: Baishideng Publishing Group Inc
  • Idioma: Inglês
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  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

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