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Metabolism of the designer drug 4-bromo-2,5-dimethoxyphenethylamine (2C-B) in mice, after acute administration

Carmo, Helena ; Boer, Douwe de ; Remião, Fernando ; Carvalho, Félix ; Reys, Lesseps A. dos ; Bastos, Maria de Lourdes

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2004, Vol.811 (2), p.143-152 [Periódico revisado por pares]

Elsevier B.V

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  • Título:
    Metabolism of the designer drug 4-bromo-2,5-dimethoxyphenethylamine (2C-B) in mice, after acute administration
  • Autor: Carmo, Helena ; Boer, Douwe de ; Remião, Fernando ; Carvalho, Félix ; Reys, Lesseps A. dos ; Bastos, Maria de Lourdes
  • Assuntos: 2C-B ; Designer drugs of abuse ; Metabolism ; Mice
  • É parte de: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2004, Vol.811 (2), p.143-152
  • Descrição: 4-Bromo-2,5-dimethoxyphenethylamine (2C-B) is a psychoactive drug of abuse often sold under the general street name “Ecstasy”. Recent reports on the abuse of 2C-B and analogues denote the lack of knowledge on this drug metabolism. In the present study, we investigated the metabolic profile of 2C-B in the mouse and found unchanged 2C-B and several metabolites, which could be identified by GC/MS in the mice urine. The identification of 2C-B metabolites may give important clues for the biological and toxicological effects of this drug of abuse and provides new important data for forensic analysis on samples taken from 2C-B abusers.
  • Editor: Elsevier B.V
  • Idioma: Inglês
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