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Injury to peribiliary glands and vascular plexus before liver transplantation predicts formation of non-anastomotic biliary strictures

op den Dries, Sanna ; Westerkamp, Andrie C ; Karimian, Negin ; Gouw, Annette S.H ; Bruinsma, Bote G ; Markmann, James F ; Lisman, Ton ; Yeh, Heidi ; Uygun, Korkut ; Martins, Paulo N ; Porte, Robert J

Journal of hepatology, 2014-06, Vol.60 (6), p.1172-1179 [Periódico revisado por pares]

Netherlands: Elsevier B.V

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Título:
Injury to peribiliary glands and vascular plexus before liver transplantation predicts formation of non-anastomotic biliary strictures
Autor: op den Dries, Sanna ; Westerkamp, Andrie C ; Karimian, Negin ; Gouw, Annette S.H ; Bruinsma, Bote G ; Markmann, James F ; Lisman, Ton ; Yeh, Heidi ; Uygun, Korkut ; Martins, Paulo N ; Porte, Robert J
Assuntos: Adult ; Bile duct injury ; Bile Ducts, Extrahepatic - injuries ; Bile Ducts, Extrahepatic - pathology ; Biliary complications ; Cholestasis - etiology ; Cholestasis - pathology ; Donation after cardiac death ; Epithelium - pathology ; Epithelium - physiology ; Female ; Gastroenterology and Hepatology ; Graft Survival - physiology ; Humans ; Ischemia - etiology ; Ischemia - pathology ; Ischemic cholangiopathy ; Ischemic type biliary injury ; Liver Circulation ; Liver transplantation ; Liver Transplantation - adverse effects ; Male ; Middle Aged ; Non-anastomotic biliary strictures ; Predictive Value of Tests ; Regeneration ; Regeneration - physiology ; Stem Cell Niche ; Tissue Donors
É parte de: Journal of hepatology, 2014-06, Vol.60 (6), p.1172-1179
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Descrição: Background & Aims The peribiliary glands of large bile ducts have been identified as a niche of progenitor cells that contribute to regeneration of biliary epithelium after injury. We aimed to determine whether injury to the peribiliary glands of donor livers is a risk factor for development of non-anastomotic biliary strictures (NAS) after liver transplantation. Methods In 128 liver transplant procedures, biopsies were taken from the donor bile duct and injury was assessed using an established histological grading system. Histological severity of injury was subsequently compared in liver grafts that later developed biliary structures vs. uncomplicated liver grafts. Results Luminal biliary epithelial loss >50% was observed in 91.8% of the grafts before transplantation, yet NAS occurred in only 16.4%. Periluminal peribiliary glands were more severely injured than deep peribiliary glands located near the fibromuscular layer (>50% loss in 56.9% vs. 17.5%, respectively; p <0.001). Injury of deep peribiliary glands was more prevalent and more severe in livers that later developed NAS, compared to grafts without NAS (>50% loss in 50.0% vs. 9.8%, respectively; p = 0.004). In parallel, injury of the peribiliary vascular plexus was more severe in livers that developed NAS, compared to grafts without NAS (>50% vascular changes in 57.1% vs. 20.3%; p = 0.006). Conclusion Injury of peribiliary glands and vascular plexus before transplantation is strongly associated with the occurrence of biliary strictures after transplantation. This suggests that insufficient regeneration due to loss of peribiliary glands or impaired blood supply may explain the development of biliary strictures.
Editor: Netherlands: Elsevier B.V
Idioma: Inglês

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Injury to peribiliary glands and vascular plexus before liver transplantation predicts formation of non-anastomotic biliary strictures

op den Dries, Sanna ; Westerkamp, Andrie C ; Karimian, Negin ; Gouw, Annette S.H ; Bruinsma, Bote G ; Markmann, James F ; Lisman, Ton ; Yeh, Heidi ; Uygun, Korkut ; Martins, Paulo N ; Porte, Robert J

Netherlands: Elsevier B.V

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