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Critical update on 2-methacryloyloxyethyl phosphorylcholine (MPC) polymer science

Goda, Tatsuro ; Ishihara, Kazuhiko ; Miyahara, Yuji

Journal of applied polymer science, 2015-04, Vol.132 (16), p.np-n/a [Periódico revisado por pares]

Hoboken: Blackwell Publishing Ltd

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  • Título:
    Critical update on 2-methacryloyloxyethyl phosphorylcholine (MPC) polymer science
  • Autor: Goda, Tatsuro ; Ishihara, Kazuhiko ; Miyahara, Yuji
  • Assuntos: Bioengineering ; biomaterials ; biomimetic ; Cell adhesion ; drug delivery systems ; Drugs ; Inhibitors ; molecular recognition ; Nanostructure ; Phosphorylcholine ; Protein adsorption ; surfaces and interfaces ; Surgical implants ; wear and lubrication
  • É parte de: Journal of applied polymer science, 2015-04, Vol.132 (16), p.np-n/a
  • Notas: ark:/67375/WNG-XSMPXWQ9-T
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  • Descrição: ABSTRACT 2‐Methacryloyloxyethyl phosphorylcholine (MPC) is a custom methacrylate with a zwitterionic phosphorylcholine moiety on the side chain. In the past 25 years, MPC has been used as a building block for a wide range of polymeric biomaterials because of its excellent resistance to nonspecific protein adsorption, cell adhesion, and blood coagulation. Recently, MPC polymers with specific features have been used in bioengineering and nanomedicine. This review focuses on three topics that highlight the latest findings on MPC polymers, that is, specific recognition of C‐reactive protein (CRP), cell‐membrane‐penetration abilities, and lubrication properties. These developments will extend the applications of this biomimetic material from bioinert polymers to biosensing, CRP inhibitors, prodrug carriers, subcellular bioimaging, cell manipulation, and joint replacement. © 2015 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2015, 132, 41766.
  • Editor: Hoboken: Blackwell Publishing Ltd
  • Idioma: Inglês
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  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

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