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Sirolimus for the Treatment of Airway Obstruction due to Indolent T-Lymphoblastic Proliferation

Moughames, Eric ; Kiess, Ana P. ; Akst, Lee M. ; Azar, Antoine Litzman, Jiri ; Jiri Litzman

Case Reports in Immunology, 2019, Vol.2019, p.1724083-4 [Periódico revisado por pares]

Egypt: Hindawi

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Título:
Sirolimus for the Treatment of Airway Obstruction due to Indolent T-Lymphoblastic Proliferation
Autor: Moughames, Eric ; Kiess, Ana P. ; Akst, Lee M. ; Azar, Antoine
Litzman, Jiri ; Jiri Litzman
Assuntos: Adenoid ; Airway management ; Case Report ; Chemotherapy ; Clinical trials ; Cyclosporins ; Health aspects ; Hyperplasia ; Immunosuppressive agents ; Immunotherapy ; Larynx ; Lymph nodes ; Lymphatic system ; Lymphoblasts ; Lymphoma ; Medical imaging ; Medical research ; Monoclonal antibodies ; Ostomy ; Pathology ; Radiation therapy ; Rapamycin ; Rituximab ; Sinuses ; Targeted cancer therapy ; Vincristine
É parte de: Case Reports in Immunology, 2019, Vol.2019, p.1724083-4
Notas: Academic Editor: Jiri Litzman
Descrição: Introduction. Indolent T-lymphoblastic proliferation (iT-LBP) is a rare nonmalignant entity that presents as a proliferation of T-lymphoblasts. We report a first such case with a recurrent laryngeal obstruction presentation that was successfully controlled with Sirolimus. Case presentation. This is the case of a 29-year-old female who presented with a recurrent significant lymphoid hyperplasia in the adenoid and tongue base region as well as a right cervical lymph node. After repeated adenoidectomies and tonsillectomies, and based on pathological and clinical findings she was diagnosed with iT-LBP. Trials of radiotherapy and immunotherapy with cyclosporine and rituximab all failed to control the progression of the disease. Sirolimus was finally able to restrict the growth and improve her symptoms. Conclusion. While It-LBP does not usually require treatment, it is important to report cases in which treatment was crucial for the survival of the patient, and the effective role of Sirolimus in doing so, without any major adverse effects.
Editor: Egypt: Hindawi
Idioma: Inglês

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Sirolimus for the Treatment of Airway Obstruction due to Indolent T-Lymphoblastic Proliferation

Moughames, Eric ; Kiess, Ana P. ; Akst, Lee M. ; Azar, Antoine Litzman, Jiri ; Jiri Litzman

Egypt: Hindawi

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