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Mucosal tumor vaccination delivering endogenous tumor antigens protects against pulmonary breast cancer metastases

Oltmanns, Friederike ; Vieira Antão, Ana ; Irrgang, Pascal ; Viherlehto, Vera ; Jörg, Leticia ; Schmidt, Anna ; Wagner, Jannik T ; Rückert, Michael ; Flohr, Ann-Sophie ; Geppert, Carol Imanuel ; Frey, Benjamin ; Bayer, Wibke ; Gravekamp, Claudia ; Tenbusch, Matthias ; Gaipl, Udo ; Lapuente, Dennis

Journal for immunotherapy of cancer, 2024-03, Vol.12 (3), p.e008652 [Periódico revisado por pares]

England: BMJ Publishing Group Ltd

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Título:
Mucosal tumor vaccination delivering endogenous tumor antigens protects against pulmonary breast cancer metastases
Autor: Oltmanns, Friederike ; Vieira Antão, Ana ; Irrgang, Pascal ; Viherlehto, Vera ; Jörg, Leticia ; Schmidt, Anna ; Wagner, Jannik T ; Rückert, Michael ; Flohr, Ann-Sophie ; Geppert, Carol Imanuel ; Frey, Benjamin ; Bayer, Wibke ; Gravekamp, Claudia ; Tenbusch, Matthias ; Gaipl, Udo ; Lapuente, Dennis
Assuntos: adjuvant ; Animals ; Antigens ; Antigens, Neoplasm ; Basic tumor immunology ; Breast cancer ; Cancer Vaccines - therapeutic use ; Cell division ; Cloning ; Cytomegalovirus ; Immunization ; Immunologic Memory ; Lung Neoplasms - therapy ; Lungs ; Lymphocytes ; Medical prognosis ; Melanoma ; memory ; Metastasis ; Mice ; Penicillin ; Peptides ; Radiation therapy ; radiotherapy/radioimmunotherapy ; Vaccination ; vaccine ; Vaccines
É parte de: Journal for immunotherapy of cancer, 2024-03, Vol.12 (3), p.e008652
Notas: Original research
ObjectType-Article-1
SourceType-Scholarly Journals-1
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Descrição: BackgroundGenerally, early-stage breast cancer has a good prognosis. However, if it spreads systemically, especially with pulmonary involvement, prospects worsen dramatically. Importantly, tumor-infiltrating T cells contribute to tumor control, particularly intratumoral T cells with a tissue-resident memory phenotype are associated with an improved clinical outcome.MethodsHere, we use an adenoviral vector vaccine encoding endogenous tumor-associated antigens adjuvanted with interleukin-1β to induce tumor-specific tissue-resident memory T cells (TRM) in the lung for the prevention and treatment of pulmonary metastases in the murine 4T1 breast cancer model.ResultsThe mucosal delivery of the vaccine was highly efficient in establishing tumor-specific TRM in the lung. Concomitantly, a single mucosal vaccination reduced the growth of pulmonary metastases and improved the survival in a prophylactic treatment. Vaccine-induced TRM contributed to these protective effects. In a therapeutic setting, the vaccination induced a pronounced T cell infiltration into metastases but resulted in only a minor restriction of the disease progression. However, in combination with stereotactic radiotherapy, the vaccine increased the survival time and rate of tumor-bearing mice.ConclusionIn summary, our study demonstrates that mucosal vaccination is a promising strategy to harness the power of antitumor TRM and its potential combination with state-of-the-art treatments.
Editor: England: BMJ Publishing Group Ltd
Idioma: Inglês

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Mucosal tumor vaccination delivering endogenous tumor antigens protects against pulmonary breast cancer metastases

England: BMJ Publishing Group Ltd

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