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Four distinct trajectories of tau deposition identified in Alzheimer's disease

Vogel, Jacob W ; Young, Alexandra L ; Oxtoby, Neil P ; Smith, Ruben ; Ossenkoppele, Rik ; Strandberg, Olof T ; La Joie, Renaud ; Aksman, Leon M ; Grothe, Michel J ; Iturria-Medina, Yasser ; Pontecorvo, Michael J ; Devous, Michael D ; Rabinovici, Gil D ; Alexander, Daniel C ; Lyoo, Chul Hyoung ; Evans, Alan C ; Hansson, Oskar

Nature medicine, 2021-05, Vol.27 (5), p.871-881 [Periódico revisado por pares]

United States: Nature Publishing Group

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Four distinct trajectories of tau deposition identified in Alzheimer's disease
Autor: Vogel, Jacob W ; Young, Alexandra L ; Oxtoby, Neil P ; Smith, Ruben ; Ossenkoppele, Rik ; Strandberg, Olof T ; La Joie, Renaud ; Aksman, Leon M ; Grothe, Michel J ; Iturria-Medina, Yasser ; Pontecorvo, Michael J ; Devous, Michael D ; Rabinovici, Gil D ; Alexander, Daniel C ; Lyoo, Chul Hyoung ; Evans, Alan C ; Hansson, Oskar
Assuntos: Aged ; Algorithms ; Alzheimer Disease - classification ; Alzheimer Disease - pathology ; Alzheimer's disease ; Carbolines - pharmacology ; Cerebral cortex ; Cerebral Cortex - diagnostic imaging ; Cerebral Cortex - pathology ; Clinical Medicine ; Cognitive ability ; Cognitive Dysfunction - pathology ; Cortex (temporal) ; Deposition ; Development and progression ; Diagnosis ; Female ; Health aspects ; Humans ; Klinisk medicin ; Male ; Medical and Health Sciences ; Medicin och hälsovetenskap ; Neurodegenerative diseases ; Neuroimaging - methods ; Neurologi ; Neurology ; Neurosciences ; Neurovetenskaper ; Pathology ; Phenotype ; Physiological aspects ; Positron emission ; Positron emission tomography ; Positron-Emission Tomography - methods ; Radioactive tracers ; Radiopharmaceuticals - administration & dosage ; Spatio-Temporal Analysis ; Tau protein ; Tau proteins ; tau Proteins - metabolism ; Temporal lobe ; Variability
É parte de: Nature medicine, 2021-05, Vol.27 (5), p.871-881
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JWV, OH & ACE conceptualized the work. JWV, ALY, NPO, LMA, MJP & OH contributed to analytic design. MJP, MDD, GDR, CHL & OH acquired and provided the data. RS, RO, OTS & RLJ contributed to data curation and processing. JWV analyzed the data. ALY & DCA originally created the SuStaIn algorithm, and NPO & LMA contributed to its execution. YIM created the ESM algorithm. JWV & OH drafted the manuscript. All authors interpreted the data and substantively contributed to revising the manuscript.
Author Contributions
Descrição: Alzheimer's disease (AD) is characterized by the spread of tau pathology throughout the cerebral cortex. This spreading pattern was thought to be fairly consistent across individuals, although recent work has demonstrated substantial variability in the population with AD. Using tau-positron emission tomography scans from 1,612 individuals, we identified 4 distinct spatiotemporal trajectories of tau pathology, ranging in prevalence from 18 to 33%. We replicated previously described limbic-predominant and medial temporal lobe-sparing patterns, while also discovering posterior and lateral temporal patterns resembling atypical clinical variants of AD. These 'subtypes' were stable during longitudinal follow-up and were replicated in a separate sample using a different radiotracer. The subtypes presented with distinct demographic and cognitive profiles and differing longitudinal outcomes. Additionally, network diffusion models implied that pathology originates and spreads through distinct corticolimbic networks in the different subtypes. Together, our results suggest that variation in tau pathology is common and systematic, perhaps warranting a re-examination of the notion of 'typical AD' and a revisiting of tau pathological staging.
Editor: United States: Nature Publishing Group
Idioma: Inglês

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Four distinct trajectories of tau deposition identified in Alzheimer's disease

United States: Nature Publishing Group

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