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ACE2 and ANG-(1-7) in the rat uterus during early and late gestation

Neves, Liomar A. A ; Stovall, Kathryn ; Joyner, JaNae ; Valdes, Gloria ; Gallagher, Patricia E ; Ferrario, Carlos M ; Merrill, David C ; Brosnihan, K. Bridget

American journal of physiology. Regulatory, integrative and comparative physiology, 2008-01, Vol.294 (1), p.R151-R161 [Periódico revisado por pares]

United States: American Physiological Society

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Título:
ACE2 and ANG-(1-7) in the rat uterus during early and late gestation
Autor: Neves, Liomar A. A ; Stovall, Kathryn ; Joyner, JaNae ; Valdes, Gloria ; Gallagher, Patricia E ; Ferrario, Carlos M ; Merrill, David C ; Brosnihan, K. Bridget
Assuntos: ACE inhibitors ; Amnion - metabolism ; Amnion - pathology ; Angiotensin I - metabolism ; Angiotensin II - metabolism ; Animals ; Decidua - metabolism ; Decidua - pathology ; Disease Models, Animal ; Epithelial Cells - metabolism ; Epithelial Cells - pathology ; Female ; Hypertension ; Hypertension, Pregnancy-Induced - metabolism ; Hypertension, Pregnancy-Induced - pathology ; Peptide Fragments - metabolism ; Peptides ; Peptidyl-Dipeptidase A - metabolism ; Placenta - metabolism ; Placenta - pathology ; Pregnancy ; Pregnancy, Animal - metabolism ; Rats ; Rats, Sprague-Dawley ; Ribonucleic acid ; RNA ; RNA, Messenger - metabolism ; Rodents ; Uterus - metabolism ; Uterus - pathology ; Yolk Sac - metabolism ; Yolk Sac - pathology
É parte de: American journal of physiology. Regulatory, integrative and comparative physiology, 2008-01, Vol.294 (1), p.R151-R161
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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Descrição: 1 Hypertension and Vascular Research Center and 3 Department of Obstetrics and Gynecology, Wake Forest University School of Medicine, Winston-Salem, North Carolina; and 2 Department of Nephrology, Pontificia Universidad Catolica de Chile, Santiago, Chile Submitted 15 July 2007 ; accepted in final form 29 October 2007 The present study was designed to determine ANG peptide content [ANG I, ANG II, ANG-(1-7)], ACE2 mRNA, and the immunocytochemical distribution of ANG-(1-7) and ACE2 in the uteroembryonic unit during early and late gestation in Sprague-Dawley rats and in a rat model of pregnancy-induced hypertension, the reduced uterine perfusion pressure (RUPP) model. At early pregnancy ANG-(1-7) and ACE2 staining were localized in the primary and secondary decidual zone and luminal and glandular epithelial cells. During late gestation, ANG-(1-7) and ACE2 staining was visualized in the labyrinth placenta and amniotic and yolk sac epithelium. Uterine ANG II concentration at early pregnancy was significantly decreased by 21–55% in the implantation and interimplantation sites compared with virgin rats, whereas ANG-(1-7) levels were maintained at prepregnancy levels. At late gestation, uterine concentrations of ANG I and ANG II were significantly increased (30% and 25%, respectively). In RUPP animals, ANG-(1-7) concentration is significantly reduced in the uterus (181 ± 16 vs. 372 ± 74 fmol/g of tissue) and placenta (143 ± 26 vs. 197 ± 20 fmol/g of tissue). ACE2 mRNA increased in the uterus of early pregnant compared with virgin rats, yet within the implantation site it was downregulated. At late pregnancy, ACE2 mRNA is elevated by 58% in the uterus and decreased by 59% in RUPP animals. The regulation of ANG-(1-7) and ACE2 in early and late pregnancy supports the hypothesis that ANG-(1-7) and ACE2 may act as a local autocrine/paracrine regulator throughout pregnancy, participating in the early (angiogenesis, apoptosis, and growth) and late (uteroplacental blood flow) events of pregnancy. renin-angiotensin system; implantation Address for reprint requests and other correspondence: K. B. Brosnihan, The Hypertension and Vascular Disease Center, Wake Forest Univ. School of Medicine, Medical Center Blvd. Winston-Salem, NC 27157-1032 (e-mail: bbrosnih{at}wfubmc.edu )
Editor: United States: American Physiological Society
Idioma: Inglês

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ACE2 and ANG-(1-7) in the rat uterus during early and late gestation

Neves, Liomar A. A ; Stovall, Kathryn ; Joyner, JaNae ; Valdes, Gloria ; Gallagher, Patricia E ; Ferrario, Carlos M ; Merrill, David C ; Brosnihan, K. Bridget

United States: American Physiological Society

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