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Quantitative analysis of motor performance in epilepsy patients treated with valproate

Farkas, Zsuzsanna ; Gulyás, Szilvia ; Molnár, Rita ; Szirmai, Imre ; Kamondi, Anita

Seizure (London, England), 2010-04, Vol.19 (3), p.173-177 [Periódico revisado por pares]

England: Elsevier Ltd

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Título:
Quantitative analysis of motor performance in epilepsy patients treated with valproate
Autor: Farkas, Zsuzsanna ; Gulyás, Szilvia ; Molnár, Rita ; Szirmai, Imre ; Kamondi, Anita
Assuntos: Adult ; Aged ; Anticonvulsants - administration & dosage ; Anticonvulsants - adverse effects ; Epilepsy ; Epilepsy - drug therapy ; Female ; Finger tapping ; Humans ; Male ; Middle Aged ; Motor Skills - drug effects ; Neurology ; Reaction Time - drug effects ; Repetitive hand movements ; Tremor ; Tremor - chemically induced ; Valproate ; Valproic Acid - administration & dosage ; Valproic Acid - adverse effects
É parte de: Seizure (London, England), 2010-04, Vol.19 (3), p.173-177
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Descrição: Abstract Purpose The aim of our study was to detect objective signs of deterioration of motor performance in epilepsy patients treated with chronic valproate therapy. Methods We examined 14 controls and 15 epilepsy patients receiving chronic valproate monotherapy, who had no subjective complaints related to motor function. Regularity and maximum frequency of repetitive hand and finger movements, and simple reaction time were measured. Intensity and frequency characteristics of resting and postural tremor were assessed using accelerometry. Data were statistically evaluated. Results Repetitive hand and finger movements were significantly more irregular and the maximum frequency of repetitive movements was significantly lower in the valproate group than in controls. Resting tremor peak frequency and motor reaction time of the two cohorts did not differ. Conclusions This is the first study, which quantitatively assesses motor performance of patients with epilepsy on chronic valproate therapy. The results suggest significant irregularity of repetitive hand movements and finger tapping even in patients with no motor complaints. Objective methods might help to recognize valproate-induced motor performance deterioration.
Editor: England: Elsevier Ltd
Idioma: Inglês

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Quantitative analysis of motor performance in epilepsy patients treated with valproate

Farkas, Zsuzsanna ; Gulyás, Szilvia ; Molnár, Rita ; Szirmai, Imre ; Kamondi, Anita

England: Elsevier Ltd

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