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Cancer detection in clinical practice and using blood‐based liquid biopsy: A retrospective audit of over 350 dogs

Flory, Andi ; McLennan, Lisa ; Peet, Betsy ; Kroll, Marissa ; Stuart, Deirdre ; Brown, Devon ; Stuebner, Kathy ; Phillips, Brenda ; Coomber, Brenda L. ; Woods, J. Paul ; Miller, Mairin ; Tripp, Chelsea D. ; Wolf‐Ringwall, Amber ; Kruglyak, Kristina M. ; McCleary‐Wheeler, Angela L. ; Phelps‐Dunn, Ashley ; Wong, Lilian K. ; Warren, Chelsea D. ; Brandstetter, Gina ; Rosentel, Michelle C. ; DiMarzio, Lauren R. ; O'Kell, Allison L. ; Cohen, Todd A. ; Grosu, Daniel S. ; Chibuk, Jason ; Tsui, Dana W. Y. ; Chorny, Ilya ; Rafalko, Jill M.

Journal of veterinary internal medicine, 2023-01, Vol.37 (1), p.258-267 [Peer Reviewed Journal]

Hoboken, USA: John Wiley & Sons, Inc

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Title:
Cancer detection in clinical practice and using blood‐based liquid biopsy: A retrospective audit of over 350 dogs
Author: Flory, Andi ; McLennan, Lisa ; Peet, Betsy ; Kroll, Marissa ; Stuart, Deirdre ; Brown, Devon ; Stuebner, Kathy ; Phillips, Brenda ; Coomber, Brenda L. ; Woods, J. Paul ; Miller, Mairin ; Tripp, Chelsea D. ; Wolf‐Ringwall, Amber ; Kruglyak, Kristina M. ; McCleary‐Wheeler, Angela L. ; Phelps‐Dunn, Ashley ; Wong, Lilian K. ; Warren, Chelsea D. ; Brandstetter, Gina ; Rosentel, Michelle C. ; DiMarzio, Lauren R. ; O'Kell, Allison L. ; Cohen, Todd A. ; Grosu, Daniel S. ; Chibuk, Jason ; Tsui, Dana W. Y. ; Chorny, Ilya ; Rafalko, Jill M.
Subjects: Animals ; Cancer ; cancer screening ; clinical signs ; Diagnosis ; Dog Diseases - diagnosis ; Dogs ; early stage ; Health aspects ; incidental ; liquid biopsy ; Liquid Biopsy - methods ; Liquid Biopsy - veterinary ; multicancer early detection ; Neoplasms - diagnosis ; Neoplasms - veterinary ; Oncology, Experimental ; preclinical ; Retrospective Studies ; SMALL ANIMAL
Is Part Of: Journal of veterinary internal medicine, 2023-01, Vol.37 (1), p.258-267
Notes: Funding information
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Funding information PetDx
Description: Background Guidelines‐driven screening protocols for early cancer detection in dogs are lacking, and cancer often is detected at advanced stages. Hypothesis/Objectives To examine how cancer typically is detected in dogs and whether the addition of a next‐generation sequencing‐based “liquid biopsy” test to a wellness visit has the potential to enhance cancer detection. Animals Client‐owned dogs with definitive cancer diagnoses enrolled in a clinical validation study for a novel blood‐based multicancer early detection test. Methods Retrospective medical record review was performed to establish the history and presenting complaint that ultimately led to a definitive cancer diagnosis. Blood samples were subjected to DNA extraction, library preparation, and next‐generation sequencing. Sequencing data were analyzed using an internally developed bioinformatics pipeline to detect genomic alterations associated with the presence of cancer. Results In an unselected cohort of 359 cancer‐diagnosed dogs, 4% of cases were detected during a wellness visit, 8% were detected incidentally, and 88% were detected after the owner reported clinical signs suggestive of cancer. Liquid biopsy detected disease in 54.7% (95% confidence interval [CI], 49.5%‐59.8%) of patients, including 32% of dogs with early‐stage cancer, 48% of preclinical dogs, and 84% of dogs with advanced‐stage disease. Conclusions/Clinical Importance Most cases of cancer were diagnosed after the onset of clinical signs; only 4% of dogs had cancer detected using the current standard of care (i.e., wellness visit). Liquid biopsy has the potential to increase detection of cancer when added to a dog's wellness visit.
Publisher: Hoboken, USA: John Wiley & Sons, Inc
Language: English

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Cancer detection in clinical practice and using blood‐based liquid biopsy: A retrospective audit of over 350 dogs

Hoboken, USA: John Wiley & Sons, Inc

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