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5,10-Methylenetetrahydrofolate Reductase Polymorphisms and Leukemia Risk: A HuGE Minireview

Robien, Kim ; Ulrich, Cornelia M.

American journal of epidemiology, 2003-04, Vol.157 (7), p.571-582 [Periódico revisado por pares]

Cary, NC: Oxford University Press

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Título:
5,10-Methylenetetrahydrofolate Reductase Polymorphisms and Leukemia Risk: A HuGE Minireview
Autor: Robien, Kim ; Ulrich, Cornelia M.
Assuntos: 10-methylenetetrahydrofolate reductase ; A1298C ; acute lymphocytic leukemia ; acute myelogenous leukemia ; Adolescent ; Adult ; ALL ; AML ; base pair(s) ; Biological and medical sciences ; C677T ; Case-Control Studies ; Child ; chronic lymphocytic leukemia ; chronic myelogenous leukemia ; CLL ; CML ; confidence interval ; cSHMT ; cytosolic serine hydroxymethyltransferase ; epidemiology ; FAD ; flavin adenine dinucleotide ; Folic Acid Deficiency - metabolism ; genetics ; Genetics, Population ; Hematologic and hematopoietic diseases ; Humans ; kilobases ; leukemia ; Leukemia, Lymphoid - epidemiology ; Leukemia, Lymphoid - genetics ; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis ; Medical sciences ; methionine synthase ; Methylenetetrahydrofolate Reductase (NADPH2) ; Middle Aged ; MLL ; MTHFR ; Mutation ; myeloid/lymphoid or mixed lineage leukemia ; neoplasms ; odds ratio ; Oxidoreductases Acting on CH-NH Group Donors - genetics ; Oxidoreductases Acting on CH-NH Group Donors - metabolism ; Oxidoreductases Acting on CH-NH Group Donors - physiology ; polymorphism (genetics) ; Polymorphism, Genetic ; Risk Factors ; S-adenosylmethionine ; SAM ; serine hydroxymethyltransferase ; SHMT ; tetrahydrofolate ; THF ; thymidylate synthase
É parte de: American journal of epidemiology, 2003-04, Vol.157 (7), p.571-582
Notas: ark:/67375/HXZ-34BD6323-9
istex:9F8F3C2B653AC3F86E80E68F1E51C26F1DE8A2C4
Received for publication July 12, 2002; accepted for publication October 16, 2002.
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Descrição: Leukemias commonly arise as a result of DNA translocations, inversions, or deletions in genes regulating blood cell development or homeostasis. Folate deficiency has been associated with uracil misincorporation into DNA and DNA double strand breaks during uracil excision repair, thus increasing the risk of chromosomal aberrations. Methylenetetrahydrofolate reductase (MTHFR) directs 5,10-methylenetetrahydrofolate toward methionine synthesis at the expense of DNA synthesis. Two MTHFR polymorphisms, C677T and A1298C, have been associated with reduced enzyme activity and C677T with altered distribution of intracellular folate metabolites. Rapidly replicating cell types, such as hematopoietic cells, may be especially sensitive to changes in the availability of intracellular folate. Three case-control studies have evaluated the association between MTHFR polymorphisms and the risk of acute leukemia, and they suggest that both adults and children with the variant forms of MTHFR have a decreased risk of lymphoid leukemias. However, no modification in risk has been observed for myeloid leukemias, suggesting that differences in folate requirements or susceptibility to chromosomal damage may exist between myeloid and lymphoid cells. Further investigation into the association between MTHFR polymorphisms and the risk of leukemia is warranted. It should include larger sample sizes and other polymorphisms in folate metabolism and address interactions with folate status.
Editor: Cary, NC: Oxford University Press
Idioma: Inglês

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5,10-Methylenetetrahydrofolate Reductase Polymorphisms and Leukemia Risk: A HuGE Minireview

Robien, Kim ; Ulrich, Cornelia M.

Cary, NC: Oxford University Press

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