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Yeast Surface Display System: Strategies for Improvement and Biotechnological Applications

Teymennet-Ramírez, Karla V ; Martínez-Morales, Fernando ; Trejo-Hernández, María R

Frontiers in bioengineering and biotechnology, 2022-01, Vol.9, p.794742-794742 [Periódico revisado por pares]

Switzerland: Frontiers Media S.A

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  • Título:
    Yeast Surface Display System: Strategies for Improvement and Biotechnological Applications
  • Autor: Teymennet-Ramírez, Karla V ; Martínez-Morales, Fernando ; Trejo-Hernández, María R
  • Assuntos: anchor ; Bioengineering and Biotechnology ; cell surface display ; microbial engineering ; whole cell biocatalyst ; yeast
  • É parte de: Frontiers in bioengineering and biotechnology, 2022-01, Vol.9, p.794742-794742
  • Notas: ObjectType-Article-2
    SourceType-Scholarly Journals-1
    ObjectType-Feature-3
    content type line 23
    ObjectType-Review-1
    Andre Luiz Barros De Oliveira, Federal University of Ceara, Brazil
    These authors have contributed equally to this work and share first authorship
    Edited by: José Cleiton Sousa dos Santos, University of International Integration of Afro-Brazilian Lusophony, Brazil
    Reviewed by: Roberta Bussons Rodrigues Valério, Federal University of Ceara, Brazil
    Alessandro Angelini, Ca’ Foscari University of Venice, Italy
    Dae-Hyuk Kweon, Sungkyunkwan University, South Korea
    Tiago Albuquerque, Federal University of Ceara, Brazil
  • Descrição: Yeast surface display (YSD) is a "whole-cell" platform used for the heterologous expression of proteins immobilized on the yeast's cell surface. YSD combines the advantages eukaryotic systems offer such as post-translational modifications, correct folding and glycosylation of proteins, with ease of cell culturing and genetic manipulation, and allows of protein immobilization and recovery. Additionally, proteins displayed on the surface of yeast cells may show enhanced stability against changes in temperature, pH, organic solvents, and proteases. This platform has been used to study protein-protein interactions, antibody design and protein engineering. Other applications for YSD include library screening, whole-proteome studies, bioremediation, vaccine and antibiotics development, production of biosensors, ethanol production and biocatalysis. YSD is a promising technology that is not yet optimized for biotechnological applications. This mini review is focused on recent strategies to improve the efficiency and selection of displayed proteins. YSD is presented as a cutting-edge technology for the vectorial expression of proteins and peptides. Finally, recent biotechnological applications are summarized. The different approaches described herein could allow for a better strategy cascade for increasing protein/peptide interaction and production.
  • Editor: Switzerland: Frontiers Media S.A
  • Idioma: Inglês
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