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Quantification of aromatase binding in the female human brain using [11C]cetrozole positron emission tomography

Jonasson, My ; Nordeman, Patrik ; Eriksson, Jonas ; Wilking, Helena ; Wikström, Johan ; Takahashi, Kayo ; Niwa, Takashi ; Hosoya, Takamitsu ; Watanabe, Yasuyoshi ; Antoni, Gunnar ; Sundström Poromaa, Inger ; Lubberink, Mark ; Comasco, Erika

Journal of neuroscience research, 2020-11, Vol.98 (11), p.2208-2218 [Peer Reviewed Journal]

United States: Wiley Subscription Services, Inc

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  • Title:
    Quantification of aromatase binding in the female human brain using [11C]cetrozole positron emission tomography
  • Author: Jonasson, My ; Nordeman, Patrik ; Eriksson, Jonas ; Wilking, Helena ; Wikström, Johan ; Takahashi, Kayo ; Niwa, Takashi ; Hosoya, Takamitsu ; Watanabe, Yasuyoshi ; Antoni, Gunnar ; Sundström Poromaa, Inger ; Lubberink, Mark ; Comasco, Erika
  • Subjects: 17β-Estradiol ; Androstenedione ; Aromatase ; Basis functions ; Binding ; Brain ; Cerebellum ; cetrozole ; Computed tomography ; Emission analysis ; Estrone ; Evaluation ; kinetic modeling ; Magnetic resonance ; Mapping ; Medical imaging ; Positron emission ; Positron emission tomography ; Regression analysis ; Sex hormones ; Testosterone ; Tissues ; Tomography ; women
  • Is Part Of: Journal of neuroscience research, 2020-11, Vol.98 (11), p.2208-2218
  • Notes: Edited by Constanza Cortes. Associate Editor: Eric M. Prager. Reviewed by Andrea Varrone.
    Mark Lubberink and Erika Comasco shared authorship.
    ObjectType-Article-1
    SourceType-Scholarly Journals-1
    ObjectType-Feature-2
    content type line 23
  • Description: Aromatase, the enzyme that in the brain converts testosterone and androstenedione to estradiol and estrone, respectively, is a putative key factor in psychoneuroendocrinology. In vivo assessment of aromatase was performed to evaluate tracer kinetic models and optimal scan duration, for quantitative analysis of the aromatase positron emission tomography (PET) ligand [11C]cetrozole. Anatomical magnetic resonance and 90‐min dynamic [11C]cetrozole PET‐CT scans were performed on healthy women. Volume of interest (VOI)‐based analyses with a plasma‐input function were performed using the single‐tissue and two‐tissue (2TCM) reversible compartment models and plasma‐input Logan analysis. Additionally, the simplified reference tissue model (SRTM), Logan reference tissue model (LRTM), and standardized uptake volume ratio model, with cerebellum as reference region, were evaluated. Parametric images were generated and regionally averaged voxel values were compared with VOI‐based analyses of the reference tissue models. The optimal reference model was used for evaluation of a decreased scan duration. Differences between the plasma‐input‐ and reference tissue‐based methods and comparisons between scan durations were assessed by linear regression. The [11C]cetrozole time–activity curves were best described by the 2TCM. SRTM nondisplaceable binding potential (BPND), with cerebellum as reference region, can be used to estimate [11C]cetrozole binding and generated robust and quantitatively accurate results for a reduced scan duration of 60 min. Receptor parametric mapping, a basis function implementation of SRTM, as well as LRTM, produced quantitatively accurate parametric images, showing BPND at the voxel level. As PET tracer, [11C]cetrozole can be employed for relatively short brain scans to measure aromatase binding using a reference tissue‐based approach. Quantification of the binding of [11C]cetrozole to aromatase in the brain is best done using the two‐tissue reversible compartment model, or the simplified reference tissue model with the cerebellum as reference region. Receptor parametric mapping and Logan reference tissue model are suitable for parametric mapping. One hour of data acquisition is sufficient for the quantification.
  • Publisher: United States: Wiley Subscription Services, Inc
  • Language: English
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