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The circadian clock ensures successful DNA replication in cyanobacteria

Liao, Yi ; Rust, Michael J

Proceedings of the National Academy of Sciences - PNAS, 2021-05, Vol.118 (20), p.1 [Periódico revisado por pares]

United States: National Academy of Sciences

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Título:
The circadian clock ensures successful DNA replication in cyanobacteria
Autor: Liao, Yi ; Rust, Michael J
Assuntos: Bacterial Proteins - genetics ; Bacterial Proteins - metabolism ; Biological clocks ; Biological Sciences ; Cell cycle ; Cell Cycle - genetics ; Chromosomes ; Circadian Clocks - genetics ; Circadian rhythm ; Circadian Rhythm - genetics ; Circadian rhythms ; Computer Simulation ; Cyanobacteria ; Deoxyribonucleic acid ; Disruption ; DNA ; DNA biosynthesis ; DNA Replication ; Gene Expression Regulation, Bacterial ; Genomes ; Mathematical models ; Metabolism ; Misalignment ; Models, Statistical ; Night ; Photoperiod ; Replication ; Replication forks ; Synechococcus - genetics ; Synechococcus - growth & development ; Synechococcus - metabolism
É parte de: Proceedings of the National Academy of Sciences - PNAS, 2021-05, Vol.118 (20), p.1
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
Author contributions: Y.L. and M.J.R. designed research; Y.L. performed research; Y.L. contributed new reagents/analytic tools; Y.L. analyzed data; and Y.L. and M.J.R. wrote the paper.
Edited by Jay C. Dunlap, Geisel School of Medicine at Dartmouth, Hanover, NH, and approved April 8, 2021 (received for review October 28, 2020)
Descrição: Disruption of circadian rhythms causes decreased health and fitness, and evidence from multiple organisms links clock disruption to dysregulation of the cell cycle. However, the function of circadian regulation for the essential process of DNA replication remains elusive. Here, we demonstrate that in the cyanobacterium , a model organism with the simplest known circadian oscillator, the clock generates rhythms in DNA replication to minimize the number of open replication forks near dusk that would have to complete after sunset. Metabolic rhythms generated by the clock ensure that resources are available early at night to support any remaining replication forks. Combining mathematical modeling and experiments, we show that metabolic defects caused by clock-environment misalignment result in premature replisome disassembly and replicative abortion in the dark, leaving cells with incomplete chromosomes that persist through the night. Our study thus demonstrates that a major function of this ancient clock in cyanobacteria is to ensure successful completion of genome replication in a cycling environment.
Editor: United States: National Academy of Sciences
Idioma: Inglês

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The circadian clock ensures successful DNA replication in cyanobacteria

Liao, Yi ; Rust, Michael J

United States: National Academy of Sciences

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