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Radiation Dose–Volume Effects in the Stomach and Small Bowel

Kavanagh, Brian D., M.D., M.P.H ; Pan, Charlie C., MD ; Dawson, Laura A., M.D ; Das, Shiva K., Ph.D ; Li, X. Allen, Ph.D ; Ten Haken, Randall K., Ph.D ; Miften, Moyed, Ph.D

International journal of radiation oncology, biology, physics, 2010-03, Vol.76 (3), p.S101-S107 [Periódico revisado por pares]

United States: Elsevier Inc

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Título:
Radiation Dose–Volume Effects in the Stomach and Small Bowel
Autor: Kavanagh, Brian D., M.D., M.P.H ; Pan, Charlie C., MD ; Dawson, Laura A., M.D ; Das, Shiva K., Ph.D ; Li, X. Allen, Ph.D ; Ten Haken, Randall K., Ph.D ; Miften, Moyed, Ph.D
Assuntos: Antineoplastic Combined Chemotherapy Protocols - adverse effects ; BODY ; DIGESTIVE SYSTEM ; DOSES ; GASTROINTESTINAL TRACT ; HAZARDS ; HEALTH HAZARDS ; Hematology, Oncology and Palliative Medicine ; Humans ; Intestine, Small - diagnostic imaging ; Intestine, Small - radiation effects ; MEDICINE ; Models, Biological ; NUCLEAR MEDICINE ; ORGANS ; QUANTEC ; RADIATION DOSES ; Radiation Injuries - complications ; Radiation therapy ; Radiation Tolerance ; Radiography ; RADIOLOGY ; RADIOLOGY AND NUCLEAR MEDICINE ; RADIOTHERAPY ; Radiotherapy Dosage ; Risk ; Small bowel ; STOMACH ; Stomach - diagnostic imaging ; Stomach - radiation effects ; SURGERY ; THERAPY ; TOXICITY
É parte de: International journal of radiation oncology, biology, physics, 2010-03, Vol.76 (3), p.S101-S107
Descrição: Published data suggest that the risk of moderately severe (≥Grade 3) radiation-induced acute small-bowel toxicity can be predicted with a threshold model whereby for a given dose level, D, if the volume receiving that dose or greater (VD) exceeds a threshold quantity, the risk of toxicity escalates. Estimates of VD depend on the means of structure segmenting ( e.g., V15 = 120 cc if individual bowel loops are outlined or V45 = 195 cc if entire peritoneal potential space of bowel is outlined). A similar predictive model of acute toxicity is not available for stomach. Late small-bowel/stomach toxicity is likely related to maximum dose and/or volume threshold parameters qualitatively similar to those related to acute toxicity risk. Concurrent chemotherapy has been associated with a higher risk of acute toxicity, and a history of abdominal surgery has been associated with a higher risk of late toxicity.
Editor: United States: Elsevier Inc
Idioma: Inglês

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Radiation Dose–Volume Effects in the Stomach and Small Bowel

Kavanagh, Brian D., M.D., M.P.H ; Pan, Charlie C., MD ; Dawson, Laura A., M.D ; Das, Shiva K., Ph.D ; Li, X. Allen, Ph.D ; Ten Haken, Randall K., Ph.D ; Miften, Moyed, Ph.D

United States: Elsevier Inc

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