skip to main content
Idioma:
Primo Search
Clear Search Box
Search in: Busca Geral
Busca Avançada
Busca por Índices

Phosphorescent Oxygen Sensor with Dendritic Protection and Two-Photon Absorbing Antenna

Briñas, Raymond P ; Troxler, Thomas ; Hochstrasser, Robin M ; Vinogradov, Sergei A

Journal of the American Chemical Society, 2005-08, Vol.127 (33), p.11851-11862 [Periódico revisado por pares]

Washington, DC: American Chemical Society

Texto completo disponível

Citações Citado por
  • Título:
    Phosphorescent Oxygen Sensor with Dendritic Protection and Two-Photon Absorbing Antenna
  • Autor: Briñas, Raymond P ; Troxler, Thomas ; Hochstrasser, Robin M ; Vinogradov, Sergei A
  • Assuntos: Absorption ; Analytical chemistry ; Biosensing Techniques ; Chemistry ; Exact sciences and technology ; General, instrumentation ; Lasers ; Luminescent Measurements ; Metalloporphyrins - chemical synthesis ; Metalloporphyrins - chemistry ; Microscopy, Fluorescence, Multiphoton ; Nanotechnology - methods ; Oxygen - analysis ; Photons ; Platinum - chemistry ; Sensitivity and Specificity
  • É parte de: Journal of the American Chemical Society, 2005-08, Vol.127 (33), p.11851-11862
  • Notas: istex:45752D18A378FE342E6FBD69A60C6BF1507F190D
    ark:/67375/TPS-W3H0ZH86-D
    Department of Chemistry.
    Department of Biochemistry and Biophysics.
  • Descrição: Imaging oxygen in 3D with submicron spatial resolution can be made possible by combining phosphorescence quenching technique with multiphoton laser scanning microscopy. Because Pt and Pd porphyrin-based phosphorescent dyes, traditionally used as phosphors in biological oxygen measurements, exhibit extremely low two-photon absorption (2PA) cross-sections, we designed a nanosensor for oxygen, in which a 2P absorbing antenna is coupled to a metalloporphyrin core via intramolecular energy transfer (ET) with the purpose of amplifying the 2PA induced phosphorescence of the metalloporphyrin. The central component of the device is a polyfunctionalized Pt porphyrin, whose triplet state emission at ambient temperatures is strong, occurs in the near infrared and is sensitive to O2. The 2PA chromophores are chosen in such a way that their absorption is maximal in the near infrared (NIR) window of tissue (e.g., 700−900 nm), while their fluorescence is overlapped with the absorption band(s) of the core metalloporphyrin, ensuring an efficient antenna-core resonance ET. The metalloporphyrin-antenna construct is embedded inside the protecting dendritic jacket, which isolates the core from interactions with biological macromolecules, controls diffusion of oxygen and makes the entire sensor water-soluble. Several Pt porphyrin-coumarin based sensors were synthesized and their photophyics studied to evaluate the proposed design.
  • Editor: Washington, DC: American Chemical Society
  • Idioma: Inglês
Links
Voltar para lista de resultados

  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

Buscando em bases de dados remotas. Favor aguardar.