Idioma:

Deep Cortical Layers Are Activated Directly by Thalamus

Constantinople, Christine M. ; Bruno, Randy M.

Science (American Association for the Advancement of Science), 2013-06, Vol.340 (6140), p.1591-1594 [Periódico revisado por pares]

Washington, DC: American Association for the Advancement of Science

Texto completo disponível

Citações Citado por

Enviar para

Título:
Deep Cortical Layers Are Activated Directly by Thalamus
Autor: Constantinople, Christine M. ; Bruno, Randy M.
Assuntos: Animals ; Biological and medical sciences ; Blocking ; Brain ; Evoked Potentials, Somatosensory ; Fundamental and applied biological sciences. Psychology ; Information dissemination ; Joints ; Neocortex - cytology ; Neocortex - drug effects ; Neocortex - physiology ; Neurology ; Neurons ; Neurons - drug effects ; Neurons - physiology ; Pharmacology ; Rats ; Rats, Wistar ; Recording ; Stimuli ; Synapses - drug effects ; Synapses - physiology ; Thalamus ; Thalamus - cytology ; Thalamus - drug effects ; Thalamus - physiology ; Vertebrates: nervous system and sense organs
É parte de: Science (American Association for the Advancement of Science), 2013-06, Vol.340 (6140), p.1591-1594
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Descrição: The thalamocortical (TC) projection to layer 4 (L4) is thought to be the main route by which sensory organs communicate with cortex. Sensory information is believed to then propagate through the cortical column along the L4→ L2/3→L5/6 pathway. Here, we show that sensory-evoked responses of L5/6 neurons in rats derive instead from direct TC synapses. Many L5/6 neurons exhibited sensory-evoked postsynaptic potentials with the same latencies as L4. Paired in vivo recordings from L5/6 neurons and thalamic neurons revealed substantial convergence of direct TC synapses onto diverse types of infragranular neurons, particularly in L5B. Pharmacological inactivation of L4 had no effect on sensory-evoked synaptic input to L5/6 neurons. L4 is thus not an obligatory distribution hub for cortical activity, and thalamus activates two separate, independent "strata" of cortex in parallel.
Editor: Washington, DC: American Association for the Advancement of Science
Idioma: Inglês

Links

Voltar para lista de resultados

Realização: Logos de Redes Sociais:

Deep Cortical Layers Are Activated Directly by Thalamus

Constantinople, Christine M. ; Bruno, Randy M.

Washington, DC: American Association for the Advancement of Science

Buscando em bases de dados remotas. Favor aguardar.