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Back and forth: History of and new insights on the vertebrate lymphatic valve

Shin, Masahiro ; Lawson, Nathan D.

Development, growth & differentiation, 2021-12, Vol.63 (9), p.523-535 [Periódico revisado por pares]

Japan: Wiley Subscription Services, Inc

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  • Título:
    Back and forth: History of and new insights on the vertebrate lymphatic valve
  • Autor: Shin, Masahiro ; Lawson, Nathan D.
  • Assuntos: Animals ; Cell size ; Circulatory system ; Danio rerio ; Endothelial Cells ; Extracellular matrix ; Genetic analysis ; Homeostasis ; Lymphatic system ; lymphatic valve ; lymphatic vessel ; Lymphatic Vessels ; Mice ; Morphogenesis ; Phylogeny ; Rare diseases ; REGULAR ARTICLES ; Review ; Valves ; zebrafish ; Zebrafish - genetics
  • É parte de: Development, growth & differentiation, 2021-12, Vol.63 (9), p.523-535
  • Notas: Communicating Editor: Tetsuya Nakamura
    ObjectType-Article-2
    SourceType-Scholarly Journals-1
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    ObjectType-Review-1
  • Descrição: Lymphatic valves develop from pre‐existing endothelial cells through a step‐wise process involving complex changes in cell shape and orientation, along with extracellular matrix interactions, to form two intraluminal leaflets. Once formed, valves prevent back‐flow within the lymphatic system to ensure drainage of interstitial fluid back into the circulatory system, thereby serving a critical role in maintaining fluid homeostasis. Despite the extensive anatomical characterization of lymphatic systems across numerous genus and species dating back several hundred years, valves were largely thought to be phylogenetically restricted to mammals. Accordingly, most insights into molecular and genetic mechanisms involved in lymphatic valve development have derived from mouse knockouts, as well as rare diseases in humans. However, we have recently used a combination of imaging and genetic analysis in the zebrafish to demonstrate that valves are a conserved feature of the teleost lymphatic system. Here, we provide a historical overview of comparative lymphatic valve anatomy together with recent efforts to define molecular pathways that contribute to lymphatic valve morphogenesis. Finally, we integrate our findings in zebrafish with previous work and highlight the benefits that this model provides for investigating lymphatic valve development. Discovery of lymphatic valve in zebrafish. The valve is structurally and genetically conserved.
  • Editor: Japan: Wiley Subscription Services, Inc
  • Idioma: Inglês
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  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

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