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Early‐life gut microbiome and egg allergy

Fazlollahi, M. ; Chun, Y. ; Grishin, A. ; Wood, R. A. ; Burks, A. W. ; Dawson, P. ; Jones, S. M. ; Leung, D. Y. M. ; Sampson, H. A. ; Sicherer, S. H. ; Bunyavanich, S.

Allergy (Copenhagen), 2018-07, Vol.73 (7), p.1515-1524 [Periódico revisado por pares]

Denmark: Blackwell Publishing Ltd

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  • Título:
    Early‐life gut microbiome and egg allergy
  • Autor: Fazlollahi, M. ; Chun, Y. ; Grishin, A. ; Wood, R. A. ; Burks, A. W. ; Dawson, P. ; Jones, S. M. ; Leung, D. Y. M. ; Sampson, H. A. ; Sicherer, S. H. ; Bunyavanich, S.
  • Assuntos: Age ; Age Factors ; Case-Control Studies ; Children ; Ecological monitoring ; egg allergy ; Egg Hypersensitivity - etiology ; egg sensitization ; Female ; Food allergies ; food allergy ; Food hypersensitivity ; Gastrointestinal Microbiome - immunology ; Humans ; Immunization ; Immunoglobulin E ; Immunoglobulin E - immunology ; Infant ; Intestinal microflora ; Lachnospiraceae ; Male ; Metabolism ; Metagenome ; Metagenomics ; microbiome ; Microbiomes ; Microbiota ; Phylogeny ; purine ; RNA, Ribosomal, 16S ; rRNA 16S ; Skin ; Skin tests ; Statistical analysis
  • É parte de: Allergy (Copenhagen), 2018-07, Vol.73 (7), p.1515-1524
  • Notas: Funding information
    This study was supported by the National Institutes of Health (U19AI066738, U01AI066560, K08AI093538, R01AI118833) and the Department of Scientific Computing at the Icahn School of Medicine at Mount Sinai. The study was also supported by the National Center for Research Resources (NCRR)/National Institutes of Health (NIH), UL1 TR000154 from the NIH/National Center for Advancing Translational Sciences (National Jewish), UL1 TR000067 (Mount Sinai), UL1 TR000039 (Arkansas), UL 1 RR024128 (North Carolina), and UL1 RR 025005 (Johns Hopkins) from the NCRR.
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    Contributions: SB directed the study. SS, HS, RW, AWB, SMJ, DYL led the recruitment of subjects and phenotypic characterization. AG directed sample acquisition and processing. PD, AG and SB curated the clinical data. MF, YC, and SB designed and performed the statistical and computational analyses. SB and MF wrote the manuscript. MF, YC, AG, RW, AWB, PD, SMJ, DYL, HS, SS, and SB edited the manuscript. All authors contributed significantly to the work presented in this paper.
  • Descrição: Background Gut microbiota may play a role in egg allergy. We sought to examine the association between early‐life gut microbiota and egg allergy. Methods We studied 141 children with egg allergy and controls from the multicenter Consortium of Food Allergy Research study. At enrollment (age 3 to 16 months), fecal samples were collected, and clinical evaluation, egg‐specific IgE measurement, and egg skin prick test were performed. Gut microbiome was profiled by 16S rRNA sequencing. Analyses for the primary outcome of egg allergy at enrollment, and the secondary outcomes of egg sensitization at enrollment and resolution of egg allergy by age 8 years, were performed using Quantitative Insights into Microbial Ecology, Phylogenetic Investigation of Communities by Reconstruction of Unobserved States, and Statistical Analysis of Metagenomic Profiles. Results Compared to controls, increased alpha diversity and distinct taxa (PERMANOVA P = 5.0 × 10−4) characterized the early‐life gut microbiome of children with egg allergy. Genera from the Lachnospiraceae, Streptococcaceae, and Leuconostocaceae families were differentially abundant in children with egg allergy. Predicted metagenome functional analyses showed differential purine metabolism by the gut microbiota of egg‐allergic subjects (Kruskal‐Wallis Padj = 0.021). Greater gut microbiome diversity and genera from Lachnospiraceae and Ruminococcaceae were associated with egg sensitization (PERMANOVA P = 5.0 × 10−4). Among those with egg allergy, there was no association between early‐life gut microbiota and egg allergy resolution by age 8 years. Conclusion The distinct early‐life gut microbiota in egg‐allergic and egg‐sensitized children identified by our study may point to targets for preventive or therapeutic intervention.
  • Editor: Denmark: Blackwell Publishing Ltd
  • Idioma: Inglês
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