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Lipid metabolism genetic risk score interacts with the Brazilian Healthy Eating Index Revised and its components to influence the odds for dyslipidemia in a cross-sectional population-based survey in Brazil

Tatiane Mieko de Meneses Fujii Marina Maintinguer Norde; Regina Mara Fisberg; Dirce Maria Lobo Marchioni; Marcelo Macedo Rogero

Nutrition And Health London v.25, n.2, p. 119-126, 2019

London 2019

Localização: FSP - Faculdade de Saúde Pública    (HNT-30/2019 )(Acessar)

  • Título:
    Lipid metabolism genetic risk score interacts with the Brazilian Healthy Eating Index Revised and its components to influence the odds for dyslipidemia in a cross-sectional population-based survey in Brazil
  • Autor: Tatiane Mieko de Meneses Fujii
  • Marina Maintinguer Norde; Regina Mara Fisberg; Dirce Maria Lobo Marchioni; Marcelo Macedo Rogero
  • Assuntos: LIPÍDEOS; DOENÇAS CARDIOVASCULARES; METABOLISMO DE GORDURA; NUTRIGENÔMICA
  • É parte de: Nutrition And Health London v.25, n.2, p. 119-126, 2019
  • Notas: Disponível em: . Acesso em: 04 fev. 2020
  • Descrição: Background:Dyslipidemia can be influenced by genetic and dietary risk factors.Aim:This study set out to investigatediet and genetic variations in Brazilian people in a cross-sectional population-based survey and to analyze the relationshipbetween single nucleotide polymorphisms (SNPs) of genes involved in lipid metabolism and cardiometabolic-relatedphenotypes using a genetic risk score (GRS).Methods:We recruited 228 adults (mean age 36.5 years) who partici-pated in the Health Survey of Sa ̃o Paulo (HS-SP), Brazil. Clinical and anthropometric parameters, as well as the interactionbetween the GRS and the Brazilian Healthy Eating Index Revised (BHEI-R) were evaluated. We analyzed the relationshipbetween SNPs inAPOA5(rs662799),APOB(rs693, rs1367117),LDLR(rs688, rs5925) andLIPC(rs2070895, rs1800588) andcardiometabolic-related phenotypes using a GRS.Results:High-density lipoprotein cholesterol (HDLC) levels wereassociated with the BHEI-R (p¼0.026;b¼ 0.183) and with its SoFAAS component (solid fats, alcoholic beverages andadded sugars) (p¼0.007;b¼0.279). Non-HDL cholesterol levels were associated with the BHEI-R vegetable component(p¼0.015;b¼0.002) and the meat, eggs and beans component (p¼0.003;b¼0.007). Triacylglycerol levels were associatedwith the BHEI-R vegetable component (p¼0.027;b¼0.003); the meat, eggs and beans component (p¼0.041;b¼0.001);and the total protein component (p¼0.013;b¼0.032). Significant effects were observed for the interactions between theGRS and both the BHEI-R oils component (p¼0.019) and the SoFAAS component (p<0.001) on the dyslipidemia risk.Conclusions:The evaluation of dietary quality, especially fat quality, together with the lipid metabolism GRS could be auseful tool to manage cardiometabolic risk
  • Editor: London
  • Data de criação/publicação: 2019
  • Formato: p. 119-126.
  • Idioma: Inglês
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  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

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