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Antimicrobial wound dressing nanofiber mats from multicomponent (chitosan/silver-NPs/polyvinyl alcohol) systems

Abdelgawad, Abdelrahman M. ; Hudson, Samuel M. ; Rojas, Orlando J.

Carbohydrate polymers, 2014-01, Vol.100 (1), p.166-178 [Periódico revisado por pares]

Kidlington: Elsevier Ltd

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Título:
Antimicrobial wound dressing nanofiber mats from multicomponent (chitosan/silver-NPs/polyvinyl alcohol) systems
Autor: Abdelgawad, Abdelrahman M. ; Hudson, Samuel M. ; Rojas, Orlando J.
Assuntos: Anti-Infective Agents - chemistry ; Anti-Infective Agents - pharmacology ; Antimicrobial ; Applied sciences ; Bandages - microbiology ; Biological and medical sciences ; Chitosan ; Chitosan - chemistry ; Composites ; Drug Carriers - chemistry ; Electrospinning ; Escherichia coli - drug effects ; Exact sciences and technology ; Forms of application and semi-finished materials ; Glucose - chemistry ; Green Chemistry Technology ; Medical sciences ; Metal Nanoparticles - chemistry ; Nanofibers - chemistry ; Polymer industry, paints, wood ; Polyvinyl alcohol ; Polyvinyl Alcohol - chemistry ; Reducing Agents - chemistry ; Silver - chemistry ; Silver nanoparticles ; Silver Nitrate - chemistry ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases ; Technology of polymers ; Technology. Biomaterials. Equipments ; Temperature ; Wounds and Injuries
É parte de: Carbohydrate polymers, 2014-01, Vol.100 (1), p.166-178
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
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Descrição: ► 20nm Ag-NPs in high concentration (3142ppm) prepared in chitosan solution. ► High PVA/CS-Ag-NPs blending ratio (60/40, v/v) were established. ► Lower fiber diameter was obtained by increasing chitosan and Ag-NPs content. ► Superior antimicrobial activity of PVA/CS-Ag-NPs nanofibers mats. Novel hybrid nanomaterials have been developed for antimicrobial applications. Here we introduce a green route to produce antibacterial nanofiber mats loaded with silver nanoparticles (Ag-NPs, 25nm diameter) enveloped in chitosan after reduction with glucose. The nanofiber mats were obtained from colloidal dispersions of chitosan-based Ag-NPs blended with polyvinyl alcohol. Nanofibers (150nm average diameter and narrow size distribution) were obtained by electrospinning and cross-linked with glutaraldhyde. The effect of crosslinking on the release of silver was studied by atomic absorption spectroscopy. Antimicrobial activity was studied by the viable cell-counting; mats loaded with silver and control samples (chitosan/PVA) with different degrees of cross-linking were compared for their effectiveness in reducing or halting the growth of aerobic bacteria. The results showed superior properties and synergistic antibacterial effects by combining chitosan with Ag-NPs.
Editor: Kidlington: Elsevier Ltd
Idioma: Inglês

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Antimicrobial wound dressing nanofiber mats from multicomponent (chitosan/silver-NPs/polyvinyl alcohol) systems

Abdelgawad, Abdelrahman M. ; Hudson, Samuel M. ; Rojas, Orlando J.

Kidlington: Elsevier Ltd

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