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Synthesis and physicochemical characteristics of Ag-doped hydroxyapatite nanoparticles, and their potential biomedical applications

Sebastiammal, Saleth ; Lesly Fathima, Arul Sigamani ; Alarifi, Saud ; Mahboob, Shahid ; Henry, Johnson ; Kavipriya, M.R. ; Govindarajan, Marimuthu ; Nicoletti, Marcello ; Vaseeharan, Baskaralingam

Environmental research, 2022-07, Vol.210, p.112979-112979, Article 112979 [Periódico revisado por pares]

Netherlands: Elsevier Inc

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  • Título:
    Synthesis and physicochemical characteristics of Ag-doped hydroxyapatite nanoparticles, and their potential biomedical applications
  • Autor: Sebastiammal, Saleth ; Lesly Fathima, Arul Sigamani ; Alarifi, Saud ; Mahboob, Shahid ; Henry, Johnson ; Kavipriya, M.R. ; Govindarajan, Marimuthu ; Nicoletti, Marcello ; Vaseeharan, Baskaralingam
  • Assuntos: Ag-nanostructure ; Biomaterials ; Green nanotechnology ; HeLa cell Lines
  • É parte de: Environmental research, 2022-07, Vol.210, p.112979-112979, Article 112979
  • Notas: ObjectType-Article-1
    SourceType-Scholarly Journals-1
    ObjectType-Feature-2
    content type line 23
  • Descrição: In this present scenario, hydroxyapatite (HAp) nanostructures were synthesized through green routes for biomedical applications, particularly remediation towards human pathogens and cancer cells. The present study aims at forming non-toxic and eco-friendly silver (Ag+) doped HAp using Polyethylene glycol (PEG), Cetyl Trimethyl ammonium bromide (CTAB) and curcumin. Ag+ doped HAp nanoparticles (NPs) were prepared by the sol-gel method with a cube and rod-like morphology. Ag-HApNPs showed a sharp and well-defined diffraction peak, which possesses the hexagonal crystalline structure with space group P63/m. The Fourier-transform infrared spectroscopy and Raman spectra confirmed the formation of Ag-HApNPs, and the bandgap values were obtained using UV-DRS analysis. The Ag-HApNPs with PEG, CTAB and curcumin might be fabricated materials were examined against antibacterial, antifungal, antioxidant, and cytotoxic activities, which provided exemplary biomedical applications. Overall, Ag-HApNPs can be used as potential drug delivery and perspectives to control multidrug-resistant pathogens. •Silver (Ag) doped hydroxyapatite nanoparticles (Ag-HApNPs) were synthesized.•Ag-HApNPs were characterized by XRD, FTIR, SEM, TEM, Raman and UV-DRS analysis.•Ag-HApNPs possess excellent antibacterial and antifungal activities.•Ag-HApNPs exhibit free radical quenching activity as effective antioxidants.•Ag-HApNPs kill HeLa cells and are effective anticancer agents.
  • Editor: Netherlands: Elsevier Inc
  • Idioma: Inglês
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  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

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