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Migration and remyelination by oligodendrocyte progenitor cells transplanted adjacent to focal areas of spinal cord inflammation

Wang, Yanping ; Piao, Jing-Hua ; Larsen, Eric C. ; Kondo, Yoichi ; Duncan, Ian D.

Journal of neuroscience research, 2011-11, Vol.89 (11), p.1737-1746 [Periódico revisado por pares]

Hoboken: Wiley Subscription Services, Inc., A Wiley Company

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Título:
Migration and remyelination by oligodendrocyte progenitor cells transplanted adjacent to focal areas of spinal cord inflammation
Autor: Wang, Yanping ; Piao, Jing-Hua ; Larsen, Eric C. ; Kondo, Yoichi ; Duncan, Ian D.
Assuntos: Animal models ; Animals ; Axons ; Cell activation ; Cell Differentiation - physiology ; Cell migration ; Cell Movement - physiology ; Central nervous system ; Degeneration ; Demyelinating diseases ; Demyelinating Diseases - metabolism ; Demyelinating Diseases - pathology ; Demyelinating Diseases - physiopathology ; Demyelination ; Female ; Glial stem cells ; Gliosis ; Green fluorescent protein ; Inflammation ; Inflammatory diseases ; Leukocyte migration ; Macrophages ; Microglia ; Multiple sclerosis ; Myelin Sheath - pathology ; Myelin Sheath - physiology ; Myelination ; Myelitis - metabolism ; Myelitis - pathology ; Myelitis - physiopathology ; Nervous system ; Neural Stem Cells - cytology ; Neural Stem Cells - physiology ; Neural Stem Cells - transplantation ; Oligodendrocytes ; Oligodendroglia - cytology ; Oligodendroglia - physiology ; Oligodendroglia - transplantation ; Rats ; Rats, Sprague-Dawley ; Spinal cord ; Spinal Cord - metabolism ; Spinal Cord - pathology ; Spinal Cord - physiopathology ; Toll-like receptor ; zymosan
É parte de: Journal of neuroscience research, 2011-11, Vol.89 (11), p.1737-1746
Notas: istex:B4A71D182103814D02399D775C6EFC3985530145
ArticleID:JNR22716
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Descrição: Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system. Exogenous cell replacement in MS lesions has been proposed as a means of achieving remyelination when endogenous remyelination has failed. However, the ability of exogenous cells to remyelinate axons in the presence of inflammation remains uncertain. We have explored the remyelinating capacity of an oligodendrocyte progenitor cell line CG‐4 transduced with the GFP gene and transplanted adjacent to a zymosan‐induced focal demyelination model in the rat spinal cord. The resulting zymosan‐induced lesions were characterized by persistent macrophage/microglia activation, focal demyelination, degeneration of axons, and reactive astrogliosis. GFP+ CG‐4 cells were found to migrate preferentially toward the inflammatory lesion and survive inside the lesion. A proportion of GFP+ CG‐4 cells differentiated into mature oligodendrocytes and remyelinated axons within the lesion. These findings suggest that grafted oligodendrocyte progenitors may migrate toward areas of inflammation in the adult rat spinal cord, where they can survive and differentiate into myelinating oligodendrocytes. © 2011 Wiley‐Liss, Inc.
Editor: Hoboken: Wiley Subscription Services, Inc., A Wiley Company
Idioma: Inglês

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Migration and remyelination by oligodendrocyte progenitor cells transplanted adjacent to focal areas of spinal cord inflammation

Wang, Yanping ; Piao, Jing-Hua ; Larsen, Eric C. ; Kondo, Yoichi ; Duncan, Ian D.

Hoboken: Wiley Subscription Services, Inc., A Wiley Company

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