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Mind the feline coronavirus: Comparison with SARS-CoV-2

Gao, Yong-yu ; Liang, Xiang-yu ; Wang, Qian ; Zhang, Shuang ; Zhao, Han ; Wang, Kai ; Hu, Gui-xue ; Liu, William J. ; Gao, Feng-shan

Gene, 2022-05, Vol.825, p.146443-146443, Article 146443 [Periódico revisado por pares]

Netherlands: Elsevier B.V

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  • Título:
    Mind the feline coronavirus: Comparison with SARS-CoV-2
  • Autor: Gao, Yong-yu ; Liang, Xiang-yu ; Wang, Qian ; Zhang, Shuang ; Zhao, Han ; Wang, Kai ; Hu, Gui-xue ; Liu, William J. ; Gao, Feng-shan
  • Assuntos: Animals ; Cats ; Coronavirus, Feline - genetics ; Coronavirus, Feline - metabolism ; COVID-19 - veterinary ; Feline coronavirus ; Protein Binding ; Receptor ; Receptor-binding domain ; Review ; SARS-CoV-2 ; Spike Glycoprotein, Coronavirus - chemistry ; Spike protein
  • É parte de: Gene, 2022-05, Vol.825, p.146443-146443, Article 146443
  • Notas: ObjectType-Article-2
    SourceType-Scholarly Journals-1
    ObjectType-Feature-1
    ObjectType-Review-3
    content type line 23
    These authors contributed equally to this work.
  • Descrição: •The cross-species of FCoV and SARS-CoV-2 between cats and human was identified.•The RBDs of FCoV and SARS-CoV-2 both have polymeric cleavage sites.•Feline ACE2 receptor play a key role in SARS-CoV-2 infection to cats.•Cats are potential intermediate host for SARS-CoV-2 transmission. Both feline coronavirus (FCoV) and SARS-CoV-2 are coronaviruses that infect cats and humans, respectively. However, cats have been shown to be susceptible to SARS-CoV-2, and FCoV also had been shown to infect human. To elucidate the relationship between FCoV and SARS-CoV-2, we highlight the main characteristics of the genome, the receptor usage, and the correlation of the receptor-binding domain (RBD) of spike proteins in FCoV and SARS-CoV-2. It is demonstrated that FCoV and SARS-CoV-2 are closely related to the main characteristics of the genome, receptor usage, and RBD of spike proteins with similar furin cleavage sites. In particular, the affinity of the conserved feline angiotensin-converting enzyme 2 (fACE2) receptor to the RBD of SARS-CoV-2 suggests that cats are susceptible to SARS-CoV-2. In addition, cross-species of coronaviruses between cats and humans or other domesticated animals are also discussed. This review sheds light on cats as potential intermediate hosts for SARS-CoV-2 transmission, and cross-species transmission or zoonotic infection of FCoV and SARS-CoV-2 between cats and humans was identified.
  • Editor: Netherlands: Elsevier B.V
  • Idioma: Inglês
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  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

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