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Complexation of hydroxamate-based siderophores with cobalt-desferricoprogen complex on fungi

Farkas, Etelka ; Szabo, Orsolya ; Gyemant, Gyongyi ; Szaniszlo, Szilvia ; Szabo, Zsuzsa ; Pocsi, Istvan

Transition metal chemistry (Weinheim), 2018-05-01, Vol.43 (4), p.355 [Periódico revisado por pares]

Springer

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  • Título:
    Complexation of hydroxamate-based siderophores with cobalt-desferricoprogen complex on fungi
  • Autor: Farkas, Etelka ; Szabo, Orsolya ; Gyemant, Gyongyi ; Szaniszlo, Szilvia ; Szabo, Zsuzsa ; Pocsi, Istvan
  • Assuntos: Analysis ; Cobalt ; Fungi
  • É parte de: Transition metal chemistry (Weinheim), 2018-05-01, Vol.43 (4), p.355
  • Descrição: Byline: Etelka Farkas (1), Orsolya Szabo (1), Gyongyi Gyemant (1), Szilvia Szaniszlo (2), Zsuzsa Szabo (2), Istvan Pocsi (2) Solution equilibrium results for Co(II) and Co(III) complexes of two natural hydroxamate-based siderophores, the exocyclic desferricrocin (DFR) and the endocyclic triacetylfusarinine (TAF) are presented. The three hydroxamate chelating functions of TAF were found to complete the octahedral coordination sphere of a Co(II) ion in stepwise processes, but following the coordination of two hydroxamates of DFR practically in one step, the third function, most probably because of sterical reasons, remained uncoordinated. A comparison with corresponding results for the previously studied acyclic desferrioxamine B (DFB) and desferricoprogen (DFC) provided some information about the effects of the molecular framework of siderophores on their cobalt-binding ability. The oxidation of the central metal ion under basic conditions and investigation of the cobalt(III) complexes by cyclic voltammetry were also made. Compared to Fe(III), by several orders of magnitude, higher stability complexes were formed with Co(III). The possibility of any effect of the Co(III)-siderophore complex on microbial Fe(III) uptake was tested by investigation of the antifungal effect of Co(III)-DFC in comparison with that of CoCl.sub.2 on two fungi cultures, Penicillium brevicompactum and Aspergillus fumigatus. Author Affiliation: (1) 0000 0001 1088 8582, grid.7122.6, Department of Inorganic and Analytical Chemistry, Faculty of Science and Technology, University of Debrecen, Debrecen, POB 21, H-4010, Hungary (2) 0000 0001 1088 8582, grid.7122.6, Department of Biotechnology and Microbiology, Faculty of Science and Technology, University of Debrecen, Debrecen, POB 63, H-4010, Hungary Article History: Registration Date: 07/03/2018 Received Date: 17/01/2018 Accepted Date: 07/03/2018 Online Date: 14/03/2018 Article note: Electronic supplementary material The online version of this article ( material, which is available to authorized users.
  • Editor: Springer
  • Idioma: Inglês

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