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Antivirals against animal viruses

Villa, T.G. ; Feijoo-Siota, L. ; Rama, J.L.R. ; Ageitos, J.M.

Biochemical pharmacology, 2017-06, Vol.133, p.97-116 [Periódico revisado por pares]

England: Elsevier Inc

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Título:
Antivirals against animal viruses
Autor: Villa, T.G. ; Feijoo-Siota, L. ; Rama, J.L.R. ; Ageitos, J.M.
Assuntos: Amino Acid Sequence ; Animals ; Antiviral Agents - classification ; Antiviral Agents - pharmacology ; Antiviral Agents - therapeutic use ; Antiviral peptides and enzybiotics ; Antivirals from animal cells ; Antivirals from bacteria ; Antivirals from fungi ; Antivirals from plants ; DNA, Viral - antagonists & inhibitors ; DNA, Viral - genetics ; Humans ; Synthetic antivirals ; Virus Diseases - drug therapy ; Virus Diseases - genetics ; Viruses - drug effects ; Viruses - genetics ; Viruses - metabolism
É parte de: Biochemical pharmacology, 2017-06, Vol.133, p.97-116
Notas: ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Review-1
Descrição: [Display omitted] Antivirals are compounds used since the 1960s that can interfere with viral development. Some of these antivirals can be isolated from a variety of sources, such as animals, plants, bacteria or fungi, while others must be obtained by chemical synthesis, either designed or random. Antivirals display a variety of mechanisms of action, and while some of them enhance the animal immune system, others block a specific enzyme or a particular step in the viral replication cycle. As viruses are mandatory intracellular parasites that use the host’s cellular machinery to survive and multiply, it is essential that antivirals do not harm the host. In addition, viruses are continually developing new antiviral resistant strains, due to their high mutation rate, which makes it mandatory to continually search for, or develop, new antiviral compounds. This review describes natural and synthetic antivirals in chronological order, with an emphasis on natural compounds, even when their mechanisms of action are not completely understood, that could serve as the basis for future development of novel and/or complementary antiviral treatments.
Editor: England: Elsevier Inc
Idioma: Inglês

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Antivirals against animal viruses

Villa, T.G. ; Feijoo-Siota, L. ; Rama, J.L.R. ; Ageitos, J.M.

England: Elsevier Inc

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