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Cryo-EM of full-length α-synuclein reveals fibril polymorphs with a common structural kernel
Cryo-EM of full-length α-synuclein reveals fibril polymorphs with a common structural kernel
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Cryo-EM of full-length α-synuclein reveals fibril polymorphs with a common structural kernel

Li, Binsen ; Ge, Peng ; Murray, Kevin A ; Sheth, Phorum ; Zhang, Meng ; Nair, Gayatri ; Sawaya, Michael R ; Shin, Woo Shik ; Boyer, David R ; Ye, Shulin ; Eisenberg, David S ; Zhou, Z Hong ; Jiang, Lin

Nature communications, 2018-09, Vol.9 (1), p.3609-10, Article 3609 [Periódico revisado por pares]

England: Nature Publishing Group

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2
α-Synuclein aggregation nucleates through liquid-liquid phase separation
α-Synuclein aggregation nucleates through liquid-liquid phase separation
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α-Synuclein aggregation nucleates through liquid-liquid phase separation

Ray, Soumik ; Singh, Nitu ; Kumar, Rakesh ; Patel, Komal ; Pandey, Satyaprakash ; Datta, Debalina ; Mahato, Jaladhar ; Panigrahi, Rajlaxmi ; Navalkar, Ambuja ; Mehra, Surabhi ; Gadhe, Laxmikant ; Chatterjee, Debdeep ; Sawner, Ajay Singh ; Maiti, Siddhartha ; Bhatia, Sandhya ; Gerez, Juan Atilio ; Chowdhury, Arindam ; Kumar, Ashutosh ; Padinhateeri, Ranjith ; Riek, Roland ; Krishnamoorthy, G ; Maji, Samir K

Nature chemistry, 2020-08, Vol.12 (8), p.705-716 [Periódico revisado por pares]

England: Nature Publishing Group

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3
α-Synuclein in Central Nervous System and from Erythrocytes, Mammalian Cells, and Escherichia coli Exists Predominantly as Disordered Monomer
α-Synuclein in Central Nervous System and from Erythrocytes, Mammalian Cells, and Escherichia coli Exists Predominantly as Disordered Monomer
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α-Synuclein in Central Nervous System and from Erythrocytes, Mammalian Cells, and Escherichia coli Exists Predominantly as Disordered Monomer

Fauvet, Bruno ; Mbefo, Martial K. ; Fares, Mohamed-Bilal ; Desobry, Carole ; Michael, Sarah ; Ardah, Mustafa T. ; Tsika, Elpida ; Coune, Philippe ; Prudent, Michel ; Lion, Niels ; Eliezer, David ; Moore, Darren J. ; Schneider, Bernard ; Aebischer, Patrick ; El-Agnaf, Omar M. ; Masliah, Eliezer ; Lashuel, Hilal A.

The Journal of biological chemistry, 2012-05, Vol.287 (19), p.15345-15364 [Periódico revisado por pares]

United States: Elsevier Inc

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4
Systemic Exosomal Delivery of shRNA Minicircles Prevents Parkinsonian Pathology
Systemic Exosomal Delivery of shRNA Minicircles Prevents Parkinsonian Pathology
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Systemic Exosomal Delivery of shRNA Minicircles Prevents Parkinsonian Pathology

Izco, María ; Blesa, Javier ; Schleef, Martin ; Schmeer, Marco ; Porcari, Riccardo ; Al-Shawi, Raya ; Ellmerich, Stephan ; de Toro, María ; Gardiner, Chris ; Seow, Yiqi ; Reinares-Sebastian, Alejandro ; Forcen, Raquel ; Simons, J. Paul ; Bellotti, Vittorio ; Cooper, J. Mark ; Alvarez-Erviti, Lydia

Molecular therapy, 2019-12, Vol.27 (12), p.2111-2122 [Periódico revisado por pares]

United States: Elsevier Inc

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5
Alpha-synuclein at the intracellular and the extracellular side: functional and dysfunctional implications
Alpha-synuclein at the intracellular and the extracellular side: functional and dysfunctional implications
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Alpha-synuclein at the intracellular and the extracellular side: functional and dysfunctional implications

Ottolini, Denis ; Calí, Tito ; Szabò, Ildikò ; Brini, Marisa

Biological chemistry, 2017-01, Vol.398 (1), p.77-100 [Periódico revisado por pares]

Germany: De Gruyter

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6
Structural basis of membrane disruption and cellular toxicity by α-synuclein oligomers
Structural basis of membrane disruption and cellular toxicity by α-synuclein oligomers
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Structural basis of membrane disruption and cellular toxicity by α-synuclein oligomers

Fusco, Giuliana ; Chen, Serene W. ; Williamson, Philip T. F. ; Cascella, Roberta ; Perni, Michele ; Jarvis, James A. ; Cecchi, Cristina ; Vendruscolo, Michele ; Chiti, Fabrizio ; Cremades, Nunilo ; Ying, Liming ; Dobson, Christopher M. ; De Simone, Alfonso

Science (American Association for the Advancement of Science), 2017-12, Vol.358 (6369), p.1440-1443 [Periódico revisado por pares]

United States: American Association for the Advancement of Science

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7
Structures of α-synuclein filaments from human brains with Lewy pathology
Structures of α-synuclein filaments from human brains with Lewy pathology
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Structures of α-synuclein filaments from human brains with Lewy pathology

Yang, Yang ; Shi, Yang ; Schweighauser, Manuel ; Zhang, Xianjun ; Kotecha, Abhay ; Murzin, Alexey G ; Garringer, Holly J ; Cullinane, Patrick W ; Saito, Yuko ; Foroud, Tatiana ; Warner, Thomas T ; Hasegawa, Kazuko ; Vidal, Ruben ; Murayama, Shigeo ; Revesz, Tamas ; Ghetti, Bernardino ; Hasegawa, Masato ; Lashley, Tammaryn ; Scheres, Sjors H W ; Goedert, Michel

Nature (London), 2022-10, Vol.610 (7933), p.791-795 [Periódico revisado por pares]

England: Nature Publishing Group

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8
Selective imaging of internalized proteopathic α-synuclein seeds in primary neurons reveals mechanistic insight into transmission of synucleinopathies
Selective imaging of internalized proteopathic α-synuclein seeds in primary neurons reveals mechanistic insight into transmission of synucleinopathies
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Selective imaging of internalized proteopathic α-synuclein seeds in primary neurons reveals mechanistic insight into transmission of synucleinopathies

Karpowicz, Richard J. ; Haney, Conor M. ; Mihaila, Tiberiu S. ; Sandler, Raizel M. ; Petersson, E. James ; Lee, Virginia M.-Y.

The Journal of biological chemistry, 2017-08, Vol.292 (32), p.13482-13497 [Periódico revisado por pares]

United States: Elsevier Inc

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9
DJ‐1 deficiency impairs autophagy and reduces alpha‐synuclein phagocytosis by microglia
DJ‐1 deficiency impairs autophagy and reduces alpha‐synuclein phagocytosis by microglia
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DJ‐1 deficiency impairs autophagy and reduces alpha‐synuclein phagocytosis by microglia

Nash, Yuval ; Schmukler, Eran ; Trudler, Dorit ; Pinkas‐Kramarski, Ronit ; Frenkel, Dan

Journal of neurochemistry, 2017-12, Vol.143 (5), p.584-594 [Periódico revisado por pares]

England: Blackwell Publishing Ltd

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10
Alpha-synuclein induces lysosomal rupture and cathepsin dependent reactive oxygen species following endocytosis
Alpha-synuclein induces lysosomal rupture and cathepsin dependent reactive oxygen species following endocytosis
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Alpha-synuclein induces lysosomal rupture and cathepsin dependent reactive oxygen species following endocytosis

Freeman, David ; Cedillos, Rudy ; Choyke, Samantha ; Lukic, Zana ; McGuire, Kathleen ; Marvin, Shauna ; Burrage, Andrew M ; Sudholt, Stacey ; Rana, Ajay ; O'Connor, Christopher ; Wiethoff, Christopher M ; Campbell, Edward M Kahle, Philipp J.

PloS one, 2013-04, Vol.8 (4), p.e62143-e62143 [Periódico revisado por pares]

United States: Public Library of Science

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