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Fine-mapping and functional studies highlight potential causal variants for rheumatoid arthritis and type 1 diabetes
Fine-mapping and functional studies highlight potential causal variants for rheumatoid arthritis and type 1 diabetes
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Fine-mapping and functional studies highlight potential causal variants for rheumatoid arthritis and type 1 diabetes

Westra, Harm-Jan ; Martínez-Bonet, Marta ; Onengut-Gumuscu, Suna ; Lee, Annette ; Luo, Yang ; Teslovich, Nikola ; Worthington, Jane ; Martin, Javier ; Huizinga, Tom ; Klareskog, Lars ; Rantapaa-Dahlqvist, Solbritt ; Chen, Wei-Min ; Quinlan, Aaron ; Todd, John A ; Eyre, Steve ; Nigrovic, Peter A ; Gregersen, Peter K ; Rich, Stephen S ; Raychaudhuri, Soumya

Nature genetics, 2018-10, Vol.50 (10), p.1366-1374 [Periódico revisado por pares]

United States: Nature Publishing Group

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Pathogenic implications for autoimmune mechanisms derived by comparative eQTL analysis of CD4+ versus CD8+ T cells
Pathogenic implications for autoimmune mechanisms derived by comparative eQTL analysis of CD4+ versus CD8+ T cells
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Pathogenic implications for autoimmune mechanisms derived by comparative eQTL analysis of CD4+ versus CD8+ T cells

Kasela, Silva ; Kisand, Kai ; Tserel, Liina ; Kaleviste, Epp ; Remm, Anu ; Fischer, Krista ; Esko, Tõnu ; Westra, Harm-Jan ; Fairfax, Benjamin P ; Makino, Seiko ; Knight, Julian C ; Franke, Lude ; Metspalu, Andres ; Peterson, Pärt ; Milani, Lili Lappalainen, Tuuli

PLoS genetics, 2017-03, Vol.13 (3), p.e1006643-e1006643 [Periódico revisado por pares]

United States: Public Library of Science

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3
IMPACT: Genomic Annotation of Cell-State-Specific Regulatory Elements Inferred from the Epigenome of Bound Transcription Factors
IMPACT: Genomic Annotation of Cell-State-Specific Regulatory Elements Inferred from the Epigenome of Bound Transcription Factors
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IMPACT: Genomic Annotation of Cell-State-Specific Regulatory Elements Inferred from the Epigenome of Bound Transcription Factors

Amariuta, Tiffany ; Luo, Yang ; Gazal, Steven ; Davenport, Emma E. ; van de Geijn, Bryce ; Ishigaki, Kazuyoshi ; Westra, Harm-Jan ; Teslovich, Nikola ; Okada, Yukinori ; Yamamoto, Kazuhiko ; Price, Alkes L. ; Raychaudhuri, Soumya

American journal of human genetics, 2019-05, Vol.104 (5), p.879-895 [Periódico revisado por pares]

United States: Elsevier Inc

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4
Single-cell RNA-sequencing of peripheral blood mononuclear cells reveals widespread, context-specific gene expression regulation upon pathogenic exposure
Single-cell RNA-sequencing of peripheral blood mononuclear cells reveals widespread, context-specific gene expression regulation upon pathogenic exposure
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Single-cell RNA-sequencing of peripheral blood mononuclear cells reveals widespread, context-specific gene expression regulation upon pathogenic exposure

Oelen, Roy ; de Vries, Dylan H ; Brugge, Harm ; Gordon, M Grace ; Vochteloo, Martijn ; Ye, Chun J ; Westra, Harm-Jan ; Franke, Lude ; van der Wijst, Monique G P

Nature communications, 2022-06, Vol.13 (1), p.3267-3267, Article 3267 [Periódico revisado por pares]

England: Nature Publishing Group

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5
Inflammation status modulates the effect of host genetic variation on intestinal gene expression in inflammatory bowel disease
Inflammation status modulates the effect of host genetic variation on intestinal gene expression in inflammatory bowel disease
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Inflammation status modulates the effect of host genetic variation on intestinal gene expression in inflammatory bowel disease

Hu, Shixian ; Uniken Venema, Werna T ; Westra, Harm-Jan ; Vich Vila, Arnau ; Barbieri, Ruggero ; Voskuil, Michiel D ; Blokzijl, Tjasso ; Jansen, Bernadien H ; Li, Yanni ; Daly, Mark J ; Xavier, Ramnik J ; Dijkstra, Gerard ; Festen, Eleonora A ; Weersma, Rinse K

Nature communications, 2021-02, Vol.12 (1), p.1122-1122, Article 1122 [Periódico revisado por pares]

England: Nature Publishing Group

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6
Human disease-associated genetic variation impacts large intergenic non-coding RNA expression
Human disease-associated genetic variation impacts large intergenic non-coding RNA expression
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Human disease-associated genetic variation impacts large intergenic non-coding RNA expression

Kumar, Vinod ; Westra, Harm-Jan ; Karjalainen, Juha ; Zhernakova, Daria V ; Esko, Tõnu ; Hrdlickova, Barbara ; Almeida, Rodrigo ; Zhernakova, Alexandra ; Reinmaa, Eva ; Võsa, Urmo ; Hofker, Marten H ; Fehrmann, Rudolf S N ; Fu, Jingyuan ; Withoff, Sebo ; Metspalu, Andres ; Franke, Lude ; Wijmenga, Cisca Cheung, Vivian G.

PLoS genetics, 2013-01, Vol.9 (1), p.e1003201 [Periódico revisado por pares]

United States: Public Library of Science

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7
Disentangling the Effects of Colocalizing Genomic Annotations to Functionally Prioritize Non-coding Variants within Complex-Trait Loci
Disentangling the Effects of Colocalizing Genomic Annotations to Functionally Prioritize Non-coding Variants within Complex-Trait Loci
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Disentangling the Effects of Colocalizing Genomic Annotations to Functionally Prioritize Non-coding Variants within Complex-Trait Loci

Trynka, Gosia ; Westra, Harm-Jan ; Slowikowski, Kamil ; Hu, Xinli ; Xu, Han ; Stranger, Barbara E. ; Klein, Robert J. ; Han, Buhm ; Raychaudhuri, Soumya

American journal of human genetics, 2015-07, Vol.97 (1), p.139-152 [Periódico revisado por pares]

United States: Elsevier Inc

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8
An integrative approach for building personalized gene regulatory networks for precision medicine
An integrative approach for building personalized gene regulatory networks for precision medicine
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An integrative approach for building personalized gene regulatory networks for precision medicine

van der Wijst, Monique G P ; de Vries, Dylan H ; Brugge, Harm ; Westra, Harm-Jan ; Franke, Lude

Genome medicine, 2018-12, Vol.10 (1), p.96-15, Article 96 [Periódico revisado por pares]

England: BioMed Central Ltd

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9
Mediation analysis demonstrates that trans-eQTLs are often explained by cis-mediation: a genome-wide analysis among 1,800 South Asians
Mediation analysis demonstrates that trans-eQTLs are often explained by cis-mediation: a genome-wide analysis among 1,800 South Asians
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Mediation analysis demonstrates that trans-eQTLs are often explained by cis-mediation: a genome-wide analysis among 1,800 South Asians

Pierce, Brandon L ; Tong, Lin ; Chen, Lin S ; Rahaman, Ronald ; Argos, Maria ; Jasmine, Farzana ; Roy, Shantanu ; Paul-Brutus, Rachelle ; Westra, Harm-Jan ; Franke, Lude ; Esko, Tonu ; Zaman, Rakibuz ; Islam, Tariqul ; Rahman, Mahfuzar ; Baron, John A ; Kibriya, Muhammad G ; Ahsan, Habibul Pritchard, Jonathan K.

PLoS genetics, 2014-12, Vol.10 (12), p.e1004818-e1004818 [Periódico revisado por pares]

United States: Public Library of Science

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10
Non-coding autoimmune risk variant defines role for ICOS in T peripheral helper cell development
Non-coding autoimmune risk variant defines role for ICOS in T peripheral helper cell development
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Non-coding autoimmune risk variant defines role for ICOS in T peripheral helper cell development

Kim, Taehyeung ; Martínez-Bonet, Marta ; Wang, Qiang ; Hackert, Nicolaj ; Sparks, Jeffrey A ; Baglaenko, Yuriy ; Koh, Byunghee ; Darbousset, Roxane ; Laza-Briviesca, Raquel ; Chen, Xiaoting ; Aguiar, Vitor R C ; Chiu, Darren J ; Westra, Harm-Jan ; Gutierrez-Arcelus, Maria ; Weirauch, Matthew T ; Raychaudhuri, Soumya ; Rao, Deepak A ; Nigrovic, Peter A

Nature communications, 2024-03, Vol.15 (1), p.2150-2150 [Periódico revisado por pares]

England: Nature Publishing Group

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