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Exploration of the nicotinamide-binding site of the tankyrases, identifying 3-arylisoquinolin-1-ones as potent and selective inhibitors in vitro
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Exploration of the nicotinamide-binding site of the tankyrases, identifying 3-arylisoquinolin-1-ones as potent and selective inhibitors in vitro

Paine, Helen A. ; Nathubhai, Amit ; Woon, Esther C.Y. ; Sunderland, Peter T. ; Wood, Pauline J. ; Mahon, Mary F. ; Lloyd, Matthew D. ; Thompson, Andrew S. ; Haikarainen, Teemu ; Narwal, Mohit ; Lehtiö, Lari ; Threadgill, Michael D.

Bioorganic & Medicinal Chemistry, 09/2015, Vol.23(17), pp.5891-5908 [Periódico revisado por pares]

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Structure-based design, synthesis and evaluation in vitro of arylnaphthyridinones, arylpyridopyrimidinones and their tetrahydro derivatives as inhibitors of the tankyrases
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Structure-based design, synthesis and evaluation in vitro of arylnaphthyridinones, arylpyridopyrimidinones and their tetrahydro derivatives as inhibitors of the tankyrases

Kumpan, Katerina ; Nathubhai, Amit ; Zhang, Chenlu ; Wood, Pauline J. ; Lloyd, Matthew D. ; Thompson, Andrew S. ; Haikarainen, Teemu ; Lehtiö, Lari ; Threadgill, Michael D.

Bioorganic & Medicinal Chemistry, 07/2015, Vol.23(13), pp.3013-3032 [Periódico revisado por pares]

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Synthesis, biological evaluation and molecular modelling of N-heterocyclic dipeptide aldehydes as selective calpain inhibitors

Jones, Matthew A ; Morton, James D ; Coxon, James M ; Mcnabb, Stephen B ; Lee, Hannah Y-Y ; Aitken, Steven G ; Mehrtens, Janna M ; Robertson, Lucinda J G ; Neffe, Axel T ; Miyamoto, Shigeru ; Bickerstaffe, Roy ; Gately, Karl ; Wood, Jacqueline M ; Abell, Andrew D

Bioorganic & medicinal chemistry, 15 July 2008, Vol.16(14), pp.6911-23 [Periódico revisado por pares]

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Deste Autor:

  1. Nathubhai, Amit
  2. Wood, Pauline J
  3. Haikarainen, Teemu
  4. Lehtiö, Lari
  5. Lloyd, Matthew D.

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