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Exploration of the nicotinamide-binding site of the tankyrases, identifying 3-arylisoquinolin-1-ones as potent and selective inhibitors in vitro
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Exploration of the nicotinamide-binding site of the tankyrases, identifying 3-arylisoquinolin-1-ones as potent and selective inhibitors in vitro

Paine, Helen A. ; Nathubhai, Amit ; Woon, Esther C.Y. ; Sunderland, Peter T. ; Wood, Pauline J. ; Mahon, Mary F. ; Lloyd, Matthew D. ; Thompson, Andrew S. ; Haikarainen, Teemu ; Narwal, Mohit ; Lehtiö, Lari ; Threadgill, Michael D.

Bioorganic & Medicinal Chemistry, 09/2015, Vol.23(17), pp.5891-5908 [Periódico revisado por pares]

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Structure-based design, synthesis and evaluation in vitro of arylnaphthyridinones, arylpyridopyrimidinones and their tetrahydro derivatives as inhibitors of the tankyrases
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Structure-based design, synthesis and evaluation in vitro of arylnaphthyridinones, arylpyridopyrimidinones and their tetrahydro derivatives as inhibitors of the tankyrases

Kumpan, Katerina ; Nathubhai, Amit ; Zhang, Chenlu ; Wood, Pauline J. ; Lloyd, Matthew D. ; Thompson, Andrew S. ; Haikarainen, Teemu ; Lehtiö, Lari ; Threadgill, Michael D.

Bioorganic & Medicinal Chemistry, 07/2015, Vol.23(13), pp.3013-3032 [Periódico revisado por pares]

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Dipeptidyl nitrile inhibitors of Cathepsin L
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Dipeptidyl nitrile inhibitors of Cathepsin L

Asaad, Nabil ; Bethel, Paul A. ; Coulson, Michelle D. ; Dawson, Jack E. ; Ford, Susannah J. ; Gerhardt, Stefan ; Grist, Matthew ; Hamlin, Gordon A. ; James, Michael J. ; Jones, Emma V. ; Karoutchi, Galith I. ; Kenny, Peter W. ; Morley, Andrew D. ; Oldham, Keith ; Rankine, Neil ; Ryan, David ; Wells, Stuart L. ; Wood, Linda ; Augustin, Martin ; Krapp, Stephan ; Simader, Hannes ; Steinbacher, Stefan

Bioorganic & Medicinal Chemistry Letters, 08/2009, Vol.19(15), pp.4280-4283 [Periódico revisado por pares]

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Synthesis, biological evaluation and molecular modelling of N-heterocyclic dipeptide aldehydes as selective calpain inhibitors

Jones, Matthew A ; Morton, James D ; Coxon, James M ; Mcnabb, Stephen B ; Lee, Hannah Y-Y ; Aitken, Steven G ; Mehrtens, Janna M ; Robertson, Lucinda J G ; Neffe, Axel T ; Miyamoto, Shigeru ; Bickerstaffe, Roy ; Gately, Karl ; Wood, Jacqueline M ; Abell, Andrew D

Bioorganic & medicinal chemistry, 15 July 2008, Vol.16(14), pp.6911-23 [Periódico revisado por pares]

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Oxidized and synchrotron cleaved structures of the disulfide redox center in the N-terminal domain of Salmonella typhimurium AhpF

Roberts, Blaine R ; Wood, Zachary A ; Jönsson, Thomas J ; Poole, Leslie B ; Karplus, P Andrew

Protein science : a publication of the Protein Society, September 2005, Vol.14(9), pp.2414-20 [Periódico revisado por pares]

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