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1 |
Material Type: Artigo
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Second generation 2-pyridyl biphenyl amide inhibitors of the hedgehog pathwayCastanedo, Georgette M. ; Wang, Shumei ; Robarge, Kirk D. ; Blackwood, Elizabeth ; Burdick, Daniel ; Chang, Christine ; Dijkgraaf, Gerrit J.P. ; Gould, Stephen ; Gunzner, Janet ; Guichert, Oivin ; Halladay, Jason ; Khojasteh, Cyrus ; Lee, Leslie ; Marsters, James C. ; Murray, Lesley ; Peterson, David ; Plise, Emile ; Salphati, Laurent ; de Sauvage, Frederic J. ; Wong, Susan ; Sutherlin, Daniel P.Bioorganic & medicinal chemistry letters, 2010-11, Vol.20 (22), p.6748-6753 [Periódico revisado por pares]Amsterdam: Elsevier LtdTexto completo disponível |
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2 |
Material Type: Artigo
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Safety and efficacy of vismodegib in patients aged ≥65 years with advanced basal cell carcinomaChang, Anne Lynn S ; Lewis, Karl D ; Arron, Sarah T ; Migden, Michael R ; Solomon, James A ; Yoo, Simon ; Day, Bann-Mo ; McKenna, Edward F ; Sekulic, AleksandarOncotarget, 2016-11, Vol.5, p.76118-76124eScholarship, University of CaliforniaSem texto completo |
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3 |
Material Type: Artigo
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A slow-cycling LGR5 tumour population mediates basal cell carcinoma relapse after therapySánchez-Danés, Adriana ; Larsimont, Jean-Christophe ; Liagre, Mélanie ; Muñoz-Couselo, Eva ; Lapouge, Gaëlle ; Brisebarre, Audrey ; Dubois, Christine ; Suppa, Mariano ; Sukumaran, Vijayakumar ; Del Marmol, Véronique ; Tabernero, Josep ; Blanpain, CédricNature (London), 2018-10, Vol.562 (7727), p.434-438 [Periódico revisado por pares]England: Nature Publishing GroupTexto completo disponível |
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4 |
Material Type: Artigo
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Unprecedented Combination of Polyketide Natural Product Fragments Identifies the New Hedgehog Signaling Pathway Inhibitor GrismononeGrigalunas, Michael ; Patil, Sohan ; Krzyzanowski, Adrian ; Pahl, Axel ; Flegel, Jana ; Schölermann, Beate ; Xie, Jianing ; Sievers, Sonja ; Ziegler, Slava ; Waldmann, HerbertChemistry : a European journal, 2022-12, Vol.28 (67), p.e202202164-n/a [Periódico revisado por pares]Germany: Wiley Subscription Services, IncTexto completo disponível |
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5 |
Material Type: Artigo
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GDC-0449—A potent inhibitor of the hedgehog pathwayRobarge, Kirk D. ; Brunton, Shirley A. ; Castanedo, Georgette M. ; Cui, Yong ; Dina, Michael S. ; Goldsmith, Richard ; Gould, Stephen E. ; Guichert, Oivin ; Gunzner, Janet L. ; Halladay, Jason ; Jia, Wei ; Khojasteh, Cyrus ; Koehler, Michael F.T. ; Kotkow, Karen ; La, Hank ; LaLonde, Rebecca L. ; Lau, Kevin ; Lee, Leslie ; Marshall, Derek ; Marsters, James C. ; Murray, Lesley J. ; Qian, Changgeng ; Rubin, Lee L. ; Salphati, Laurent ; Stanley, Mark S. ; Stibbard, John H.A. ; Sutherlin, Daniel P. ; Ubhayaker, Savita ; Wang, Shumei ; Wong, Susan ; Xie, MinliBioorganic & medicinal chemistry letters, 2009-10, Vol.19 (19), p.5576-5581 [Periódico revisado por pares]Amsterdam: Elsevier LtdTexto completo disponível |
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6 |
Material Type: Artigo
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Combinations of PRI-724 Wnt/β-Catenin Pathway Inhibitor with Vismodegib, Erlotinib, or HS-173 Synergistically Inhibit Head and Neck Squamous Cancer CellsKleszcz, Robert ; Frąckowiak, Mikołaj ; Dorna, Dawid ; Paluszczak, JarosławInternational journal of molecular sciences, 2023-06, Vol.24 (13), p.10448 [Periódico revisado por pares]Switzerland: MDPI AGTexto completo disponível |
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7 |
Material Type: Artigo
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Mechanisms of hedgehog, calcium and retinoic acid signalling pathway inhibitors: Plausible modes of action along the MLL–EZH2-p53 axis in cellular growth controlManna, Soumen ; Kirtana, R. ; Roy, Ankan ; Baral, Tirthankar ; Patra, Samir KumarArchives of biochemistry and biophysics, 2023-07, Vol.742, p.109600-109600, Article 109600 [Periódico revisado por pares]United States: Elsevier IncTexto completo disponível |
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8 |
Material Type: Artigo
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Identification of a series of 4-[3-(quinolin-2-yl)-1,2,4-oxadiazol-5-yl]piperazinyl ureas as potent smoothened antagonist hedgehog pathway inhibitorsOntoria, Jesus M. ; Bufi, Laura Llauger ; Torrisi, Caterina ; Bresciani, Alberto ; Giomini, Claudia ; Rowley, Michael ; Serafini, Sergio ; Bin, Hu ; Hao, Wu ; Steinkühler, Christian ; Jones, PhilipBioorganic & medicinal chemistry letters, 2011-09, Vol.21 (18), p.5274-5282 [Periódico revisado por pares]Amsterdam: Elsevier LtdTexto completo disponível |
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9 |
Material Type: Artigo
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Identification of MK-5710 ((8aS)-8a-methyl-1,3-dioxo-2-[(1S,2R)-2-phenylcyclo- propyl]-N-(1-phenyl-1H-pyrazol-5-yl)hexahydro-imidazo[1,5-a]pyrazine-7(1H)-carboxamide), a potent smoothened antagonist for use in Hedgehog pathway dependent malignancies, Part 2Kinzel, Olaf ; Alfieri, Anna ; Altamura, Sergio ; Brunetti, Mirko ; Bufali, Simone ; Colaceci, Fabrizio ; Ferrigno, Federica ; Filocamo, Gessica ; Fonsi, Massimiliano ; Gallinari, Paola ; Malancona, Savina ; Hernando, Jose Ignacio Martin ; Monteagudo, Edith ; Orsale, Maria Vittoria ; Palumbi, Maria Cecilia ; Pucci, Vincenzo ; Rowley, Michael ; Sasso, Romina ; Scarpelli, Rita ; Steinkühler, Christian ; Jones, PhilipBioorganic & medicinal chemistry letters, 2011-08, Vol.21 (15), p.4429-4435 [Periódico revisado por pares]Amsterdam: Elsevier LtdTexto completo disponível |
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10 |
Material Type: Artigo
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Identification of MK-5710 ((8aS)-8a-methyl-1,3-dioxo-2-[(1S,2R)-2-phenylcyclopropyl]-N-(1-phenyl-1H-pyrazol-5-yl)hexahydroimid azo[1,5-a]pyrazine-7(1H)-carboxamide), a potent smoothened antagonist for use in Hedgehog pathway dependent malignancies, Part 1Malancona, Savina ; Altamura, Sergio ; Filocamo, Gessica ; Kinzel, Olaf ; Hernando, Jose Ignacio Martin ; Rowley, Michael ; Scarpelli, Rita ; Steinkühler, Christian ; Jones, PhilipBioorganic & medicinal chemistry letters, 2011-08, Vol.21 (15), p.4422-4428 [Periódico revisado por pares]Amsterdam: Elsevier LtdTexto completo disponível |