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1
The beta secretase BACE1 regulates the expression of insulin receptor in the liver
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The beta secretase BACE1 regulates the expression of insulin receptor in the liver

Meakin, Paul J ; Mezzapesa, Anna ; Benabou, Eva ; Haas, Mary E ; Bonardo, Bernadette ; Grino, Michel ; Brunel, Jean-Michel ; Desbois-Mouthon, Christèle ; Biddinger, Sudha B ; Govers, Roland ; Ashford, Michael L J ; Peiretti, Franck

Nature communications, 2018-04, Vol.9 (1), p.1306-14, Article 1306 [Periódico revisado por pares]

England: Nature Publishing Group

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2
Loss of Nrf2 markedly exacerbates nonalcoholic steatohepatitis
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Loss of Nrf2 markedly exacerbates nonalcoholic steatohepatitis

Chowdhry, Sudhir ; Nazmy, Maiiada H. ; Meakin, Paul J. ; Dinkova-Kostova, Albena T. ; Walsh, Shaun V. ; Tsujita, Tadayuki ; Dillon, John F. ; Ashford, Michael L.J. ; Hayes, John D.

Free radical biology & medicine, 2010-01, Vol.48 (2), p.357-371 [Periódico revisado por pares]

United States: Elsevier Inc

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3
Dimethyl fumarate blocks pro-inflammatory cytokine production via inhibition of TLR induced M1 and K63 ubiquitin chain formation
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Dimethyl fumarate blocks pro-inflammatory cytokine production via inhibition of TLR induced M1 and K63 ubiquitin chain formation

McGuire, Victoria A ; Ruiz-Zorrilla Diez, Tamara ; Emmerich, Christoph H ; Strickson, Sam ; Ritorto, Maria Stella ; Sutavani, Ruhcha V ; Weiβ, Anne ; Houslay, Kirsty F ; Knebel, Axel ; Meakin, Paul J ; Phair, Iain R ; Ashford, Michael L J ; Trost, Matthias ; Arthur, J Simon C

Scientific reports, 2016-08, Vol.6 (1), p.31159-31159, Article 31159 [Periódico revisado por pares]

England: Nature Publishing Group

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4
Reduction in BACE1 decreases body weight, protects against diet-induced obesity and enhances insulin sensitivity in mice
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Reduction in BACE1 decreases body weight, protects against diet-induced obesity and enhances insulin sensitivity in mice

Meakin, Paul J ; Harper, Alex J ; Hamilton, D Lee ; Gallagher, Jennifer ; McNeilly, Alison D ; Burgess, Laura A ; Vaanholt, Lobke M ; Bannon, Kirsten A ; Latcham, Judy ; Hussain, Ishrut ; Speakman, John R ; Howlett, David R ; Ashford, Michael L J

Biochemical journal, 2012-01, Vol.441 (1), p.285-296 [Periódico revisado por pares]

England: Portland Press Ltd

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5
The unfolded protein response is activated in skeletal muscle by high-fat feeding: potential role in the downregulation of protein synthesis
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The unfolded protein response is activated in skeletal muscle by high-fat feeding: potential role in the downregulation of protein synthesis

Deldicque, Louise ; Cani, Patrice D ; Philp, Andrew ; Raymackers, Jean-Marc ; Meakin, Paul J ; Ashford, Michael L J ; Delzenne, Nathalie M ; Francaux, Marc ; Baar, Keith

American journal of physiology: endocrinology and metabolism, 2010-11, Vol.299 (5), p.E695-E705 [Periódico revisado por pares]

United States: American Physiological Society

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6
Non-canonical Keap1-independent activation of Nrf2 in astrocytes by mild oxidative stress
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Non-canonical Keap1-independent activation of Nrf2 in astrocytes by mild oxidative stress

Al-Mubarak, Bashayer R. ; Bell, Karen F.S. ; Chowdhry, Sudhir ; Meakin, Paul J. ; Baxter, Paul S. ; McKay, Sean ; Dando, Owen ; Ashford, Michael L.J. ; Gazaryan, Irina ; Hayes, John D. ; Hardingham, Giles E.

Redox biology, 2021-11, Vol.47, p.102158, Article 102158 [Periódico revisado por pares]

Netherlands: Elsevier B.V

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7
Bace1-dependent amyloid processing regulates hypothalamic leptin sensitivity in obese mice
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Bace1-dependent amyloid processing regulates hypothalamic leptin sensitivity in obese mice

Meakin, Paul J ; Jalicy, Susan M ; Montagut, Gemma ; Allsop, David J P ; Cavellini, Daniella L ; Irvine, Stuart W ; McGinley, Christopher ; Liddell, Mary K ; McNeilly, Alison D ; Parmionova, Karolina ; Liu, Yu-Ru ; Bailey, Charlotte L S ; Dale, J Kim ; Heisler, Lora K ; McCrimmon, Rory J ; Ashford, Michael L J

Scientific reports, 2018-01, Vol.8 (1), p.55-55, Article 55 [Periódico revisado por pares]

England: Nature Publishing Group

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8
Mice Lacking beta2-Integrin Function Remain Glucose Tolerant in Spite of Insulin Resistance, Neutrophil Infiltration and Inflammation
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Mice Lacking beta2-Integrin Function Remain Glucose Tolerant in Spite of Insulin Resistance, Neutrophil Infiltration and Inflammation

Meakin, Paul J ; Morrison, Vicky L ; Sneddon, Claire C ; Savinko, Terhi ; Uotila, Liisa ; Jalicy, Susan M ; Gabriel, Jennie L ; Kang, Li ; Ashford, Michael L J ; Fagerholm, Susanna C Chen, Xiaoli

PloS one, 2015-09, Vol.10 (9), p.e0138872-e0138872 [Periódico revisado por pares]

United States: Public Library of Science

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9
Nrf2 target genes can be controlled by neuronal activity in the absence of Nrf2 and astrocytes
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Nrf2 target genes can be controlled by neuronal activity in the absence of Nrf2 and astrocytes

Deighton, Ruth F ; Márkus, Nóra M ; Al-Mubarak, Bashayer ; Bell, Karen F S ; Papadia, Sofia ; Meakin, Paul J ; Chowdhry, Sudhir ; Hayes, John D ; Hardingham, Giles E

Proceedings of the National Academy of Sciences - PNAS, 2014-05, Vol.111 (18), p.E1818-E1820 [Periódico revisado por pares]

United States: National Acad Sciences

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10
Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1
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Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1

Mills, Evanna L ; Ryan, Dylan G ; Prag, Hiran A ; Dikovskaya, Dina ; Menon, Deepthi ; Zaslona, Zbigniew ; Jedrychowski, Mark P ; Costa, Ana S H ; Higgins, Maureen ; Hams, Emily ; Szpyt, John ; Runtsch, Marah C ; King, Martin S ; McGouran, Joanna F ; Fischer, Roman ; Kessler, Benedikt M ; McGettrick, Anne F ; Hughes, Mark M ; Carroll, Richard G ; Booty, Lee M ; Knatko, Elena V ; Meakin, Paul J ; Ashford, Michael L J ; Modis, Louise K ; Brunori, Gino ; Sévin, Daniel C ; Fallon, Padraic G ; Caldwell, Stuart T ; Kunji, Edmund R S ; Chouchani, Edward T ; Frezza, Christian ; Dinkova-Kostova, Albena T ; Hartley, Richard C ; Murphy, Michael P ; O'Neill, Luke A

Nature (London), 2018-04, Vol.556 (7699), p.113-117 [Periódico revisado por pares]

England: Nature Publishing Group

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