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Phthalazinone Pyrazoles as Potent, Selective, and Orally Bioavailable Inhibitors of Aurora-A Kinase
Phthalazinone Pyrazoles as Potent, Selective, and Orally Bioavailable Inhibitors of Aurora-A Kinase
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Phthalazinone Pyrazoles as Potent, Selective, and Orally Bioavailable Inhibitors of Aurora-A Kinase

Prime, Michael E ; Courtney, Stephen M ; Brookfield, Frederick A ; Marston, Richard W ; Walker, Victoria ; Warne, Justin ; Boyd, Andrew E ; Kairies, Norman A ; von der Saal, Wolfgang ; Limberg, Anja ; Georges, Guy ; Engh, Richard A ; Goller, Bernhard ; Rueger, Petra ; Rueth, Matthias

Journal of medicinal chemistry, 2011-01, Vol.54 (1), p.312-319 [Periódico revisado por pares]

United States: American Chemical Society

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2
Neuroactive Steroids. 2. 3α-Hydroxy-3β-methyl-21-(4-cyano‑1H‑pyrazol-1′-yl)-19-nor-5β-pregnan-20-one (SAGE-217): A Clinical Next Generation Neuroactive Steroid Positive Allosteric Modulator of the (γ-Aminobutyric Acid)A Receptor
Neuroactive Steroids. 2. 3α-Hydroxy-3β-methyl-21-(4-cyano‑1H‑pyrazol-1′-yl)-19-nor-5β-pregnan-20-one (SAGE-217): A Clinical Next Generation Neuroactive Steroid Positive Allosteric Modulator of the (γ-Aminobutyric Acid)A Receptor
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Neuroactive Steroids. 2. 3α-Hydroxy-3β-methyl-21-(4-cyano‑1H‑pyrazol-1′-yl)-19-nor-5β-pregnan-20-one (SAGE-217): A Clinical Next Generation Neuroactive Steroid Positive Allosteric Modulator of the (γ-Aminobutyric Acid)A Receptor

Martinez Botella, Gabriel ; Salituro, Francesco G ; Harrison, Boyd L ; Beresis, Richard T ; Bai, Zhu ; Blanco, Maria-Jesus ; Belfort, Gabriel M ; Dai, Jing ; Loya, Carlos M ; Ackley, Michael A ; Althaus, Alison L ; Grossman, Scott J ; Hoffmann, Ethan ; Doherty, James J ; Robichaud, Albert J

Journal of medicinal chemistry, 2017-09, Vol.60 (18), p.7810-7819 [Periódico revisado por pares]

United States: American Chemical Society

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3
Fragment-based Differential Targeting of PPI Stabilizer Interfaces
Fragment-based Differential Targeting of PPI Stabilizer Interfaces
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Fragment-based Differential Targeting of PPI Stabilizer Interfaces

Guillory, Xavier ; Wolter, Madita ; Leysen, Seppe ; Neves, João Filipe ; Kuusk, Ave ; Genet, Sylvia ; Somsen, Bente ; Morrow, John Kenneth ; Rivers, Emma ; van Beek, Lotte ; Patel, Joe ; Goodnow, Robert ; Schoenherr, Heike ; Fuller, Nathan ; Cao, Qing ; Doveston, Richard G ; Brunsveld, Luc ; Arkin, Michelle R ; Castaldi, Paola ; Boyd, Helen ; Landrieu, Isabelle ; Chen, Hongming ; Ottmann, Christian

Journal of medicinal chemistry, 2020-07, Vol.63 (13), p.6694-6707 [Periódico revisado por pares]

American Chemical Society

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4
Neuroactive Steroids. 1. Positive Allosteric Modulators of the (γ-Aminobutyric Acid)A Receptor: Structure–Activity Relationships of Heterocyclic Substitution at C‑21
Neuroactive Steroids. 1. Positive Allosteric Modulators of the (γ-Aminobutyric Acid)A Receptor: Structure–Activity Relationships of Heterocyclic Substitution at C‑21
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Neuroactive Steroids. 1. Positive Allosteric Modulators of the (γ-Aminobutyric Acid)A Receptor: Structure–Activity Relationships of Heterocyclic Substitution at C‑21

Martinez Botella, Gabriel ; Salituro, Francesco G ; Harrison, Boyd L ; Beresis, Richard T ; Bai, Zhu ; Shen, Kaisheng ; Belfort, Gabriel M ; Loya, Carlos M ; Ackley, Michael A ; Grossman, Scott J ; Hoffmann, Ethan ; Jia, Shiling ; Wang, Jiamiao ; Doherty, James J ; Robichaud, Albert J

Journal of medicinal chemistry, 2015-04, Vol.58 (8), p.3500-3511 [Periódico revisado por pares]

United States: American Chemical Society

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5
2-Amino-3,4-dihydroquinazolines as Inhibitors of BACE-1 (β-Site APP Cleaving Enzyme):  Use of Structure Based Design to Convert a Micromolar Hit into a Nanomolar Lead
2-Amino-3,4-dihydroquinazolines as Inhibitors of BACE-1 (β-Site APP Cleaving Enzyme):  Use of Structure Based Design to Convert a Micromolar Hit into a Nanomolar Lead
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2-Amino-3,4-dihydroquinazolines as Inhibitors of BACE-1 (β-Site APP Cleaving Enzyme):  Use of Structure Based Design to Convert a Micromolar Hit into a Nanomolar Lead

Baxter, Ellen W ; Conway, Kelly A ; Kennis, Ludo ; Bischoff, François ; Mercken, Marc H ; De Winter, Hans L ; Reynolds, Charles H ; Tounge, Brett A ; Luo, Chi ; Scott, Malcolm K ; Huang, Yifang ; Braeken, Mirielle ; Pieters, Serge M. A ; Berthelot, Didier J. C ; Masure, Stefan ; Bruinzeel, Wouter D ; Jordan, Alfonzo D ; Parker, Michael H ; Boyd, Robert E ; Qu, Junya ; Alexander, Richard S ; Brenneman, Douglas E ; Reitz, Allen B

Journal of medicinal chemistry, 2007-09, Vol.50 (18), p.4261-4264 [Periódico revisado por pares]

Washington, DC: American Chemical Society

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6
Structure-Based Design and Synthesis of 1,3-Oxazinan-2-one Inhibitors of 11β-Hydroxysteroid Dehydrogenase Type 1
Structure-Based Design and Synthesis of 1,3-Oxazinan-2-one Inhibitors of 11β-Hydroxysteroid Dehydrogenase Type 1
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Structure-Based Design and Synthesis of 1,3-Oxazinan-2-one Inhibitors of 11β-Hydroxysteroid Dehydrogenase Type 1

Xu, Zhenrong ; Tice, Colin M ; Zhao, Wei ; Cacatian, Salvacion ; Ye, Yuan-Jie ; Singh, Suresh B ; Lindblom, Peter ; McKeever, Brian M ; Krosky, Paula M ; Kruk, Barbara A ; Berbaum, Jennifer ; Harrison, Richard K ; Johnson, Judith A ; Bukhtiyarov, Yuri ; Panemangalore, Reshma ; Scott, Boyd B ; Zhao, Yi ; Bruno, Joseph G ; Togias, Jennifer ; Guo, Joan ; Guo, Rong ; Carroll, Patrick J ; McGeehan, Gerard M ; Zhuang, Linghang ; He, Wei ; Claremon, David A

Journal of medicinal chemistry, 2011-09, Vol.54 (17), p.6050-6062 [Periódico revisado por pares]

United States: American Chemical Society

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7
Discovery of a Potent, Selective, Orally Bioavailable, and Efficacious Novel 2‑(Pyrazol-4-ylamino)-pyrimidine Inhibitor of the Insulin-like Growth Factor‑1 Receptor (IGF-1R)
Discovery of a Potent, Selective, Orally Bioavailable, and Efficacious Novel 2‑(Pyrazol-4-ylamino)-pyrimidine Inhibitor of the Insulin-like Growth Factor‑1 Receptor (IGF-1R)
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Discovery of a Potent, Selective, Orally Bioavailable, and Efficacious Novel 2‑(Pyrazol-4-ylamino)-pyrimidine Inhibitor of the Insulin-like Growth Factor‑1 Receptor (IGF-1R)

Degorce, Sébastien L ; Boyd, Scott ; Curwen, Jon O ; Ducray, Richard ; Halsall, Christopher T ; Jones, Clifford D ; Lach, Franck ; Lenz, Eva M ; Pass, Martin ; Pass, Sarah ; Trigwell, Catherine

Journal of medicinal chemistry, 2016-05, Vol.59 (10), p.4859-4866 [Periódico revisado por pares]

United States: American Chemical Society

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8
Nanomolar Inhibitors of Staphylococcus aureus Methionyl tRNA Synthetase with Potent Antibacterial Activity against Gram-Positive Pathogens
Nanomolar Inhibitors of Staphylococcus aureus Methionyl tRNA Synthetase with Potent Antibacterial Activity against Gram-Positive Pathogens
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Nanomolar Inhibitors of Staphylococcus aureus Methionyl tRNA Synthetase with Potent Antibacterial Activity against Gram-Positive Pathogens

JARVEST, Richard L. ; BERGE, John M. ; BERRY, Valerie ; BOYD, Helen F. ; BROWN, Murray J. ; ELDER, John S. ; FORREST, Andrew K. ; FOSBERRY, Andrew P. ; GENTRY, Daniel R. ; HIBBS, Martin J. ; JAWORSKI, Deborah D. ; O'HANLON, Peter J. ; POPE, Andrew J. ; RITTENHOUSE, Stephen ; SHEPPARD, Robert J. ; SLATER-RADOSTI, Courtney ; WORBY, Angela

Journal of medicinal chemistry, 2002-05, Vol.45 (10), p.1959-1962 [Periódico revisado por pares]

Washington, DC: American Chemical Society

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9
Identification of Novel Inhibitors of Urokinase via NMR-Based Screening
Identification of Novel Inhibitors of Urokinase via NMR-Based Screening
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Identification of Novel Inhibitors of Urokinase via NMR-Based Screening

Hajduk, Philip J ; Boyd, Steven ; Nettesheim, David ; Nienaber, Vicki ; Severin, Jean ; Smith, Richard ; Davidson, Don ; Rockway, Todd ; Fesik, Stephen W

Journal of medicinal chemistry, 2000-10, Vol.43 (21), p.3862-3866 [Periódico revisado por pares]

Washington, DC: American Chemical Society

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10
Advances toward New Antidepressants with Dual Serotonin Transporter and 5-HT1A Receptor Affinity within a Class of 3-Aminochroman Derivatives. Part 2
Advances toward New Antidepressants with Dual Serotonin Transporter and 5-HT1A Receptor Affinity within a Class of 3-Aminochroman Derivatives. Part 2
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Advances toward New Antidepressants with Dual Serotonin Transporter and 5-HT1A Receptor Affinity within a Class of 3-Aminochroman Derivatives. Part 2

Hatzenbuhler, Nicole T ; Baudy, Reinhardt ; Evrard, Deborah A ; Failli, Amedeo ; Harrison, Boyd L ; Lenicek, Steven ; Mewshaw, Richard E ; Saab, Annmarie ; Shah, Uresh ; Sze, Jean ; Zhang, Minsheng ; Zhou, Dahui ; Chlenov, Michael ; Kagan, Michael ; Golembieski, Jeannette ; Hornby, Geoffrey ; Lai, Margaret ; Smith, Deborah L ; Sullivan, Kelly M ; Schechter, Lee E ; Andree, Terrance H

Journal of medicinal chemistry, 2008-11, Vol.51 (21), p.6980-7004 [Periódico revisado por pares]

Columbus, OH: American Chemical Society

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