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Refinado por: assunto: Anatomy & Physiology remover Nome da Publicação: Bioorganic and Medicinal Chemistry Letters remover
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1
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SAR inspired by aldehyde oxidase (AO) metabolism: Discovery of novel, CNS penetrant tricyclic M PAMs

Chopko, Trevor C ; Han, Changho ; Gregro, Alison R ; Engers, Darren W ; Felts, Andrew S ; Poslusney, Mike S ; Bollinger, Katrina A ; Morrison, Ryan D ; Bubser, Michael ; Lamsal, Atin ; Luscombe, Vincent B ; Cho, Hyekyung P ; Schnetz-Boutaud, Nathalie C ; Rodriguez, Alice L ; Chang, Sichen ; Daniels, J Scott ; Stec, Donald F ; Niswender, Colleen M ; Jones, Carrie K ; Wood, Michael R ; Wood, Michael W ; Duggan, Mark E ; Brandon, Nicholas J ; Conn, P Jeffrey ; Bridges, Thomas M ; Lindsley, Craig W ; Melancon, Bruce J

Bioorganic & medicinal chemistry letters, 15 August 2019, Vol.29(16), pp.2224-2228 [Periódico revisado por pares]

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VU6005806/AZN-00016130, an advanced M positive allosteric modulator (PAM) profiled as a potential preclinical development candidate

Engers, Darren W ; Melancon, Bruce J ; Gregro, Allison R ; Bertron, Jeanette L ; Bollinger, Sean R ; Felts, Andrew S ; Konkol, Leah C ; Wood, Michael R ; Bollinger, Katrina A ; Luscombe, Vincent B ; Rodriguez, Alice L ; Jones, Carrie K ; Bubser, Michael ; Yohn, Samantha E ; Wood, Michael W ; Brandon, Nicholas J ; Dugan, Mark E ; Niswender, Colleen M ; Jeffrey Conn, P ; Bridges, Thomas M ; Lindsley, Craig W

Bioorganic & medicinal chemistry letters, 16 May 2019 [Periódico revisado por pares]

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3
Development of a novel class of potent and selective FIXa inhibitors
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Development of a novel class of potent and selective FIXa inhibitors

Zhang, Ting ; Andre, Patrick ; Bateman, Thomas J. ; Chen, Yi-Heng ; Desai, Kunal ; Ellsworth, Kenneth ; Geissler, Wayne M. ; Guo, Liangqin ; Hruza, Alan ; Jian, Tianying ; Meng, Dongfang ; Parker, Dann L. ; Qian, Xiaoxia ; Reichert, Paul ; Sherer, Edward C. ; Shu, Min ; Smith, Cameron J. ; Sonatore, Lisa M. ; Tschirret-Guth, Richard ; Nolting, Andrew F. ; Orr, Robert ; Campeau, Louis-Charles ; Araki, Kazuto ; Nishimura, Teruyuki ; Sakurada, Isao ; Wood, Harold B.

Bioorganic & Medicinal Chemistry Letters, 11/2015, Vol.25(21), pp.4945-4949 [Periódico revisado por pares]

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Discovery of AZD3514, a small-molecule androgen receptor downregulator for treatment of advanced prostate cancer

Bradbury , Robert H. ; Acton , David G. ; Broadbent , Nicola L. ; Brooks , A. Nigel ; Carr , Gregory R. ; Hatter , Glenn ; Hayter , Barry R. ; Hill , Kathryn J. ; Howe , Nicholas J. ; Jones , Rhys D.O. ; Jude , David ; Lamont , Scott G. ; Loddick , Sarah A. ; Mcfarland , Heather L. ; Parveen , Zaieda ; Rabow , Alfred A. ; Sharma-Singh , Gorkhn ; Stratton , Natalie C. ; Thomason , Andrew G. ; Trueman , Dawn ; Walker , Graeme E. ; Wells , Stuart L. ; Wilson , Joanne ; Wood , J. Matthew

Bioorganic & medicinal chemistry letters, 2013, Vol.23(7), pp.1945-1948 [Periódico revisado por pares]

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5
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design and synthesis of novel, potent and orally bioavailable N-aryl piperazine-1-carboxamide CCR2 antagonists with very high hERG selectivity

Cumming , John G. ; Bower , Justin F. ; Waterson , David ; Faull , Alan ; Poyser , Philip J. ; Turner , Paul ; Mcdermott , Benjamin ; Campbell , Andrew D. ; Hudson , Julian ; James , Michael ; Winter , Jon ; Wood , Christine

Bioorganic & medicinal chemistry letters, 2012, Vol.22(12), pp.3895-3899 [Periódico revisado por pares]

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6
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SAR and biological evaluation of 3-azabicyclo[3.1.0]hexane derivatives as μ opioid ligands

Lunn , Graham ; Roberts , Lee R. ; Content , Stephane ; Critcher , Douglas J. ; Douglas , Sara ; Fenwick , Ashley E. ; Gethin , David M. ; Goodwin , Graham ; Greenway , David ; Greenwood , Sean ; Hall , Kim ; Thomas , Martin ; Thompson , Stephen ; Williams , David ; Wood , Gavin ; Wylie , Andrew

Bioorganic & medicinal chemistry letters, 2012, Vol.22(6), pp.2200-2203 [Periódico revisado por pares]

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7
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Identification, optimisation and in vivo evaluation of oxadiazole DGAT-1 inhibitors for the treatment of obesity and diabetes

Mccoull , William ; Addie , Matthew S. ; Birch , Alan M. ; Birtles , Susan ; Buckett , Linda K. ; Butlin , Roger J. ; Bowker , Suzanne S. ; Boyd , Scott ; Chapman , Stephen ; Davies , Robert D.M. ; Donald , Craig S. ; Green , Clive P. ; Jenner , Chloe ; Kemmitt , Paul D. ; Leach , Andrew G. ; Moody , Graeme C. ; Morentin Gutierrez , Pablo ; Newcombe , Nicholas J. ; Nowak , Thorsten ; Packer , Martin J. ; Plowright , Alleyn T. ; Revill , John ; Schofield , Paul ; Sheldon , Chris ; Stokes , Steve ; Turnbull , Andrew V. ; Wang , Steven J.Y. ; Whalley , David P. ; Matthew Wood , J.

Bioorganic & medicinal chemistry letters, 2012, Vol.22(12), pp.3873-3878 [Periódico revisado por pares]

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8
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Selective non zinc binding inhibitors of MMP13

Savi, Chris De ; Morley, Andrew D ; Ting, Attilla ; Nash, Ian ; Karabelas, Kostas ; Wood, Christine M ; James, Michael ; Norris, Stephen J ; Karoutchi, Galith ; Rankine, Neil ; Hamlin, Gordon ; Macfaul, Philip A ; Ryan, David ; Baker, Sarah V ; Hargreaves, David ; Gerhardt, Stefan

Bioorganic & Medicinal Chemistry Letters, 2011, Vol.21(14), pp.4215-4219 [Periódico revisado por pares]

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9
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Discovery, optimisation and in vivo evaluation of novel GPR119 agonists

Brocklehurst, Katy J ; Broo, Anders ; Butlin, Roger J ; Brown, Hayley S ; Clarke, David S ; Davidsson, Öjvind ; Goldberg, Kristin ; Groombridge, Sam D ; Kelly, Elizabeth E ; Leach, Andrew ; Mckerrecher, Darren ; O’donnell, Charles ; Poucher, Simon ; Schofield, Paul ; Scott, James S ; Teague, Joanne ; Westgate, Leanne ; Wood, Matt J.M

Bioorganic & Medicinal Chemistry Letters, 2011, Vol.21(24), pp.7310-7316 [Periódico revisado por pares]

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10
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The identification of a selective dopamine D 2 partial agonist, D 3 antagonist displaying high levels of brain exposure

Holmes, Ian P ; Blunt, Richard J ; Lorthioir, Olivier E ; Blowers, Stephen M ; Gribble, Andy ; Payne, Andrew H ; Stansfield, Ian G ; Wood, Martyn ; Woollard, Patrick M ; Reavill, Charlie ; Howes, Claire M ; Micheli, Fabrizio ; Fabio, Romano Di ; Donati, Daniele ; Terreni, Silvia ; Hamprecht, Dieter ; Arista, Luca ; Worby, Angela ; Watson, Steve P

Bioorganic & Medicinal Chemistry Letters, 2010, Vol.20(6), pp.2013-2016 [Periódico revisado por pares]

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Deste Autor:

  1. James, Michael
  2. Luscombe, Vincent B
  3. Bubser, Michael
  4. Wood, Michael W
  5. Bollinger, Katrina A

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