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Investigating the Effects of Mixing Dynamics on Twin-Screw Granule Quality Attributes via the Development of a Physics-Based Process Map
Investigating the Effects of Mixing Dynamics on Twin-Screw Granule Quality Attributes via the Development of a Physics-Based Process Map
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Investigating the Effects of Mixing Dynamics on Twin-Screw Granule Quality Attributes via the Development of a Physics-Based Process Map

Kotamarthy, Lalith ; Karkala, Subhodh ; Dan, Ashley ; Román-Ospino, Andrés D ; Ramachandran, Rohit

Pharmaceutics, 2024-03, Vol.16 (4), p.456 [Peer Reviewed Journal]

Switzerland: MDPI AG

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2
Quantitative analysis of the effects of multi-component formulation parameters on granule and tablet properties via a combined population balance and statistical predictive model
Quantitative analysis of the effects of multi-component formulation parameters on granule and tablet properties via a combined population balance and statistical predictive model
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Quantitative analysis of the effects of multi-component formulation parameters on granule and tablet properties via a combined population balance and statistical predictive model

Dan, Ashley ; Paul, Shubhajit ; Vaswani, Haresh ; Grząbka-Zasadzińska, Aleksandra ; Thakkelapally, Anish ; Li, Jingzhe ; Sen, Koyel ; Deanne, Richard ; Tseng, Yin-Chao ; Ramachandran, Rohit

Powder technology, 2024-02, Vol.435, p.119391, Article 119391 [Peer Reviewed Journal]

Elsevier B.V

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3
End-point determination of heterogeneous formulations using inline torque measurements for a high-shear wet granulation process
End-point determination of heterogeneous formulations using inline torque measurements for a high-shear wet granulation process
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End-point determination of heterogeneous formulations using inline torque measurements for a high-shear wet granulation process

Dan, Ashley ; Vaswani, Haresh ; Šimonová, Alice ; Grząbka-Zasadzińska, Aleksandra ; Li, Jingzhe ; Sen, Koyel ; Paul, Shubhajit ; Tseng, Yin-Chao ; Ramachandran, Rohit

International journal of pharmaceutics: X, 2023-12, Vol.6, p.100188-100188, Article 100188 [Peer Reviewed Journal]

Netherlands: Elsevier B.V

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4
Twin-screw granulation: Mechanistic understanding of the effect of material properties on key granule quality attributes through the analysis of mixing dynamics and granulation rate mechanisms
Twin-screw granulation: Mechanistic understanding of the effect of material properties on key granule quality attributes through the analysis of mixing dynamics and granulation rate mechanisms
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Twin-screw granulation: Mechanistic understanding of the effect of material properties on key granule quality attributes through the analysis of mixing dynamics and granulation rate mechanisms

Kotamarthy, Lalith ; Dan, Ashley ; Karkala, Subhodh ; Parvani, Sania ; Román-Ospino, Andrés D. ; Ramachandran, Rohit

Advanced powder technology : the international journal of the Society of Powder Technology, Japan, 2023-09, Vol.34 (9), p.104137, Article 104137 [Peer Reviewed Journal]

United States: Elsevier B.V

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5
Optimization of key energy and performance metrics for drug product manufacturing
Optimization of key energy and performance metrics for drug product manufacturing
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Optimization of key energy and performance metrics for drug product manufacturing

Chen, Yingjie ; Kotamarthy, Lalith ; Dan, Ashley ; Sampat, Chaitanya ; Bhalode, Pooja ; Singh, Ravendra ; Glasser, Benjamin J. ; Ramachandran, Rohit ; Ierapetritou, Marianthi

International journal of pharmaceutics, 2023-01, Vol.631 (C), p.122487-122487, Article 122487 [Peer Reviewed Journal]

Netherlands: Elsevier B.V

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6
Development of a Granule Growth Regime Map for Twin Screw Wet Granulation Process via Data Imputation Techniques
Development of a Granule Growth Regime Map for Twin Screw Wet Granulation Process via Data Imputation Techniques
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Development of a Granule Growth Regime Map for Twin Screw Wet Granulation Process via Data Imputation Techniques

Kotamarthy, Lalith ; Sampat, Chaitanya ; Ramachandran, Rohit

Pharmaceutics, 2022-10, Vol.14 (10), p.2211 [Peer Reviewed Journal]

Basel: MDPI AG

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7
Enabling energy‐efficient manufacturing of pharmaceutical solid oral dosage forms via integrated techno‐economic analysis and advanced process modeling
Enabling energy‐efficient manufacturing of pharmaceutical solid oral dosage forms via integrated techno‐economic analysis and advanced process modeling
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Enabling energy‐efficient manufacturing of pharmaceutical solid oral dosage forms via integrated techno‐economic analysis and advanced process modeling

Sampat, Chaitanya ; Kotamarthy, Lalith ; Bhalode, Pooja ; Chen, Yingjie ; Dan, Ashley ; Parvani, Sania ; Dholakia, Zeal ; Singh, Ravendra ; Glasser, Benjamin J. ; Ierapetritou, Marianthi ; Ramachandran, Rohit

Journal of advanced manufacturing and processing, 2022-10, Vol.4 (4), p.n/a [Peer Reviewed Journal]

Hoboken, USA: John Wiley & Sons, Inc

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8
Investigating the effects of material properties on the mixing dynamics of cohesive particles in a twin screw mixer using a discrete element method approach
Investigating the effects of material properties on the mixing dynamics of cohesive particles in a twin screw mixer using a discrete element method approach
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Investigating the effects of material properties on the mixing dynamics of cohesive particles in a twin screw mixer using a discrete element method approach

Karkala, Subhodh ; Ramachandran, Rohit

Powder technology, 2022-09, Vol.409, p.117762, Article 117762 [Peer Reviewed Journal]

Elsevier B.V

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9
Optimization of screw design for continuous wet granulation: A case study of metoprolol succinate ER tablets
Optimization of screw design for continuous wet granulation: A case study of metoprolol succinate ER tablets
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Optimization of screw design for continuous wet granulation: A case study of metoprolol succinate ER tablets

Zidan, Ahmed ; Kotamarthy, Lalith ; Ramachandran, Rohit ; Ashraf, Muhammad ; O'Connor, Thomas

International journal of pharmaceutics, 2022-07, Vol.623 (C), p.121964-121964, Article 121964 [Peer Reviewed Journal]

Netherlands: Elsevier B.V

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10
Switching from batch to continuous granulation: A case study of metoprolol succinate ER tablets
Switching from batch to continuous granulation: A case study of metoprolol succinate ER tablets
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Switching from batch to continuous granulation: A case study of metoprolol succinate ER tablets

Kotamarthy, Lalith ; Feng, Xin ; Alayoubi, Alaadin ; Kumar Bolla, Pradeep ; Ramachandran, Rohit ; Ashraf, Muhammad ; O'Connor, Thomas ; Zidan, Ahmed

International journal of pharmaceutics, 2022-04, Vol.617 (C), p.121598-121598, Article 121598 [Peer Reviewed Journal]

Netherlands: Elsevier B.V

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